IndraLab

Statements

KCNH1 inhibits cell population proliferation. 8 / 11
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"In contrast to chemotherapeutic drugs, Eag1 RNAi has been shown to inhibit the proliferation of various cancer cell lines with minimal nonspecific side effects [XREF_BIBR]."
26783521
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"Open Channel Blockade of Eag1 Channels Reduces Tumor Progression in Vivo -- Because inhibition of Eag1 by the open channel blockers astemizole and imipramine has been reported to inhibit proliferation of several cell types in vitro, we tested if similar effects could be observed in vivo."
18927085
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"In addition, to further evaluate whether Eag1 suppresses cell proliferation and migration by downregulating STAT3-VEGF pathway, cells were transfected with STAT3 siRNA."
26783521
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"Previously, we showed that calcitriol via VDR inhibited Eag1 gene expression reducing breast cancer cell proliferation XREF_BIBR and Weber et al demonstrated that silencing Eag1 expression with siRNA resulted in similar antineoplastic effects XREF_BIBR."
22984610
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"The Eag blocker imipramine at 50 muM significantly inhibited the proliferation of SK-OV-3 cell lines at 72 hours of culture (P < 0.001; Figure XREF_FIG) while clofilium (100-3300 nM) did not show any effect on proliferation at any of the time points tested."
21392380
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"The proliferation of SK-OV-3 cells is significantly inhibited by both Eag and HERG blockers."
21392380
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"Imipramine or Eag shRNA significantly suppressed the proliferation of MG-63 cells in vitro and in vivo."
23450231
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"Cell proliferation of E6/E7 keratinocytes was decreased by Eag1 antibodies inhibiting channel activity and by the nonspecific Eag1 inhibitors imipramine and astemizole; the latter also increased apoptosis."
19351862