IndraLab

Statements

OGT binds USP8. 18 / 18
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"Targeting the USP8–OGT axis may emerge as a promising strategy in precision oncology for iCCA."
41301681
sparser
"Furthermore, it has been observed that SLC7A11 is regulated by the USP8-OGT axis through O-GlcNAcylation in HCC cells, and this post-translational modification of SLC7A11 is indispensable for its cystine absorption function ( xref )."
38650929
sparser
"Moreover, the mass spectrometry and co-immunoprecipitation analysis indicated that USP8 interacted with OGT."
38973004
sparser
"The USP8-OGT axis could be a potential target for iCCA therapy."
38973004
sparser
"Our findings provide potential therapeutic opportunities for iCCA by targeting USP8-OGT axis."
38973004
sparser
"USP8 interacted with OGT and enhances OGT stability."
38973004
sparser
"Moreover, the co-immunoprecipitation (IP) assay revealed that USP8 could interact with OGT in 293 T cells."
38973004
reach
"Co-IP analysis identified the interaction between USP8 and OGT."
38973004
reach
"As expected, the association between USP8 and OGT was markedly decreased upon SLK depletion (Figure 6D)."
37867237
reach
"As expected, ectopic expression of PPP1CA dephosphorylated USP8 and decreased the interaction between USP8 and OGT (Figure S6E,F, Supporting Information)."
37867237
reach
"Co‐IP analysis identified the association between OGT and USP8."
37867237
sparser
"Co-IP analysis identified the interaction between USP8 and OGT."
38973004
reach
"Besides the association between endogenous USP8 and OGT was also identified in HCCC9810 and RBE cells."
38973004
sparser
"In summary, cysteine metabolism in HCC, through key regulators such as SLC7A11, USP8–OGT, PSTK–GPX4, and γ-GCSh, establishes a complex metabolism–signaling interaction network that governs ferroptosis, antioxidant defense, and therapeutic resistance."
41074146
sparser
"USP8 Inhibitors DUB-IN-3 Suppress the Malignant Progression of iCCA by Disrupting the USP8–OGT Axis."
41301681
sparser
"Rescue experiments confirmed that OGT overexpression reversed the anti-tumor effects of USP8 knockdown, solidifying the USP8–OGT axis as a core driver of iCCA."
41301681
sparser
"Co-immunoprecipitation (Co-IP) confirmed direct USP8-OGT interaction, with USP8 promoting the stability of OGT protein levels."
41301681
sparser
"USP8 inhibitors suppress the malignant progression of iCCA by disrupting the USP8–OGT axis."
41301681