IndraLab

Statements

Copper(2+) inhibits NLRP3. 6 / 6
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"A clinically approved copper chelator, tetrathiomolybdate, inhibits the canonical NLRP3 inflammasome, but not the AIM2, NLRC4, and NLRP1 inflammasomes."
38102020
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"To further demonstrate that DSF+Cu could inhibit NF-κB activity and NLRP3-secreted IL-1β and CASP1 activation, we performed the experiment using THP-1 and BMDMs, and the results were consistent (Figure S4)."
37284442
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"A clinically approved copper chelator, tetrathiomolybdate, inhibited the canonical NLRP3 but not the AIM2, NLRC4, and NLRP1 inflammasomes or NF-kappaB-dependent priming."
29358279
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"In the lungs, for instance, CU has been shown to block the inflammatory NLRP3 pathway, which is responsible for preventing pyroptosis ( Wu et al., 2022 )."
38382713
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"Further, a copper chelator inhibited the NLRP3 and not the AIM2, NLRC4, and NLRP1 inflammasomes or NF-kappaB-dependent priming 25."
33462188
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"A study has shown that Cu depletion modulates the canonical NLRP3 pathway [56] , and reports indicate that Cu chelation inhibits Cu-dependent inflammatory cytokines [57] ."
34999205