IndraLab

Statements

ELAVL4 binds KCNA1. 13 / 13
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"The result that HuD only binds Kv1.1 mRNA in neurons treated with rapamycin supports a role for HuD in promoting Kv1.1 mRNA translation when mTORC1 is inhibited."
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"In contrast, HuD only binds Kv1.1 mRNA in neurons treated with rapamycin (with a ratio of 8.6 ± 0.7 SD, one-sample t test, P < 0.05; xref )."
23836929
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"When mTORC1 is inhibited by rapamycin, however, HuD binds Kv1.1 mRNA and miR-129 binding is inhibited, thus stimulating Kv1.1 protein synthesis."
30618607
reach
"When mTORC1 is inhibited by rapamycin, however, HuD binds Kv1.1 mRNA and miR-129 binding is inhibited, thus stimulating Kv1.1 protein synthesis."
30618607
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"HuD binding to Kv1.1 mRNA coincides with the reduced level of other HuD target mRNAs."
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"HuD binding to Kv1.1 occurs as a result of the degradation of other high-affinity targets of HuD, such as CamKIIα, GAP-43, and Homer 1a, when mTOR is inactive."
26512708
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"We thus propose that HuD binds to Kv1.1 mRNA when mTORC1 kinase is inhibited and promotes its translation (Fig. S5, right dendrite)."
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"If HuD binding to Kv1.1 mRNA requires the degradation of high affinity targets such as CaMKIIα mRNA, overexpression of CaMKIIα mRNA containing several HuD binding sites may affect the dendritic expression of Kv1.1 protein."
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"However, miR-129 competes for Kv1.1 mRNA-binding with the RNA-binding protein HuD, which acts as a positive regulator of Kv1.1 protein expression."
24570654
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"To verify the predicted binding of HuD to Kv1.1 mRNA, coimmunoprecipitation of transfected HEK293T cells was used to assess whether HuD binds directly to Kv1.1 mRNA."
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"It has recently been shown that upon inactivation of mTORC1, binding of the HuD protein to Kv1.1 overcomes miR-129 repression on Kv1.1 mRNA."
25426019
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"We next tested whether HuD binding to Kv1.1 mRNA is altered with mTORC1 kinase activity."
23836929
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"HuD binds Kv1.1 mRNA when mTORC1 kinase is inactive and overrides mTORC1 kinase–dependent repression."
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