IndraLab

Statements

CACNA1G inhibits cell population proliferation. 3 / 4
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"The Cav3.1 null mice impaired the proliferation and differentiation of the neuro-progenitor cells."
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"Notably, CACNA1G gene knock-down and the Ca V 3 channel blocker, mibefradil, significantly reduced the rate of cell proliferation in this cancer [XREF_BIBR]."
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"In human glioblastoma cells, mibefradil, a T-type Ca 2+ channel blocker with a weak L-type channel inhibiting activity [XREF_BIBR], and siRNA mediated downregulation of CACNA1G (Ca V.3.1) and CACNA1H (Ca V 3.2) reduces cell proliferation, induces apoptotic cell death, and sensitizes cells to ionizing radiation via AKT and mTORC2 axis [XREF_BIBR]."
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