IndraLab

Statements

BRCC3 binds USP5. 3 / 3
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"Ubiquitinated NLRP3 is degraded by the proteasome, whereas BRISC (Brcc36 isopeptidase complex), a deubiquitinating enzyme complex, promotes NLRP3 inflammasome activation by deubiquitination of NLRP3 [ xref , xref ]."
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"Go-CC terms included motile cilium, endoplasmic reticulum lumen, dynein complex, membrane microdomain and Brcc36 isopeptidase (BRISC) complex ( xref E)."
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"MERIT40 (BABAM1), as a RAP80-associated protein, is named as an important component of BRISC (Brcc36 isopeptidase complex) and BRCA1 (BReast-CAncer susceptibility gene 1) DNA damage repair complex A. When DNA damage occurs, BABAM1 helps to locate the repair complex to the site of damage, stabilizes the structure of the complex to cause ubiquitination at the site of damage, and trigger cell cycle G2 arrest ( xref ; xref ; xref )."
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