IndraLab

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BRD4 activates USP35. 3 / 3
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"Since BRD4 mediates the effects of USP35 on inhibiting ferroptosis in ER+ breast cancer cells (Fig. 6), we tested the effect of BRD4 inhibition on USP35-enhanced growth of ER+ breast cancer cells in vivo."
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"Consequentially, BRD4 mediated USP35-induced SLC7A11 upregulation, inhibiting ferroptosis and promoting the growth of ER+ breast cancer cells."
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"These data support that BRD4 mediates the effects of USP35 in promoting tumor growth and inhibiting ferroptosis in ER+ breast tumors."
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