IndraLab

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CTNNB1 methylates CTNNB1. 11 / 11
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"We found that nuclear beta-catenin as well as endogenously methylated beta-catenin (both in the cytoplasm and nucleus) in these two cell lines was significantly decreased by SMYD2 knockdown."
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"Lnc-β-catm promotes the interaction between β-catenin and EZH2, which further methylates β-catenin and promotes its stability, leading to Wnt/β-catenin signaling activation in liver CSCs (Zhu et al. xref )."
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"Knockdown of SMYD2 abolished beta-catenin methylation and nuclear localization of beta-catenin through the loss of the interaction with FOXM1, resulted in the downregulation of the Wnt/beta-catenin/TCF downstream genes such as c-myc and cyclin D, and subsequently induced cancer cell death."
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"Prior studies have demonstrated that SETD7 can methylate nonhistone proteins,43 45 59 including β-catenin, where SETD7 methylates β-catenin to facilitate (GSK)-3β-mediated degradation in 293T and HeLa cells."
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"Nevertheless, beta-catenin stabilization causes enhancement of nuclear beta-catenin methylation only."
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"Furthermore, the elevation of K48-Ub of β-catenin and the reduction of methylated β-catenin within nucleus in CA1 after tGCI were counteracted with AAV-USP22 treatment) (Fig. 8H)."
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"In summary, beta-catenin stabilization causes methylation of nuclear beta-catenin, and Kdm2a/b mediated demethylation is required for the degradation of beta-catenin in the nucleus.We explored whether[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These results further support that RBM3 may inhibit osteoblast-induced Wnt/β-catenin activation in PCa cells by inducing CTNNB1 m A methylation, which in turn reduces mRNA stability as well as the expression level of β-catenin."
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"Promoter methylation of β-catenin (CTNNB1) was markedly lower in low immune/β-catenin high CIC4 compared with other clusters, in particular compared with high immune CIC2 (P = 10 ; Figure 3B)."
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"In summary, β-catenin stabilization causes methylation of nuclear β-catenin, and Kdm2a/b-mediated demethylation is required for the degradation of β-catenin in the nucleus."
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"Lnc-β-catm promotes the interaction between β-catenin and EZH2, which further methylates β-catenin and promotes its stability, leading to Wnt/β-catenin signaling activation in liver CSCs (Zhu et al. 2016a)."
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