IndraLab

Statements

USP10 inhibits Proteasome. 6 / 7
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"These results suggested that coexpression of USP10 with an aggregation-prone protein inhibits proteasome activity to increase the amount of insoluble ubiquitinated proteins, thereby augmenting aggresome formation."
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"Moreover, a proteasome activity reporter YFP-CL1 indicated that USP10 together with YFP-CL1 inhibits proteasome activity (XREF_FIG F)."
30469013
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"Thus, USP10 and p62 might inhibit proteasome activity by trapping proteasome components in protein aggregates and/or aggresomes."
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"p62 and USP10 have been shown to inhibit the proteasome activity by promoting ubiquitinated protein aggregation ."
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"Clinical studies have found that USP10 is lowly expressed in liver tissue samples from NAFLD patients, and further studies have shown that USP10 inhibits proteasome-mediated degradation of SIRT6 via deubiquitination."
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"Based on USP10 induced ubiquitinated protein aggregation, we hypothesized that coexpression of USP10 with an aggregation-prone protein inhibits proteasome activity."
30469013