IndraLab

Statements

COPS5 inhibits COPS5. 5 / 5
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"Supporting CSN5 specific inhibition on mRNA levels (XREF_FIG), we found a significant reduction only in CSN5 protein levels while other CSN subunits (e.g. CSN1, CSN3 and CSN8) showed little or no change (XREF_FIG)."
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"In CSN5 knockdowns c-Jun destabilization was rescued by CSN5 overexpression, demonstrating the substrate receptor role of CSN5."
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"This result supports that the over expression of COPS5 promotes malignancy.Finally, Since COPS5 has been shown to be associated with the proliferation of DLBCL in several cell lines derived from subtypes of DLBCL (Pulvino et al., 2015), to further determine the role of COPS5 in B cell lymphoma, we depleted COPS5 in the B cell lymphoma cell lines Raji and SLVL using the CRISPR/Cas9 system."
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"We next examined whether suppression of Jab1 expression could increase the sensitivity of NPC cells to cisplatin, IR and UV by knocking down Jab1 in HONE1 and CNE2 cells."
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"A decrease or increase in intracellular CSN5 expression levels significantly decreased or increased the number of CSN5 monomers, respectively, but had no significant effect on the COP9 complex ( Fukum[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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