IndraLab

Statements



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"Blockade of NFkappaB activation by PS-1145 is enhanced by dexamethasone, which upregulates IkappaBalpha protein."

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"Dexamethasone prevents interleukin-1beta-induced nuclear factor-kappaB activation by upregulating IkappaB-alpha synthesis, in lymphoblastic cells."

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"Dexamethasone inhibits the NF-kappaB pathway by inducing IkappaBalpha in KSHV-transformed cells."

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"In primary cultures of Leydig cells, 10 -9 and 10 -7 M dexamethasone decreased levels of NR4A1 and NR5A1 mRNAs and increased those of NFKBIA mRNA."

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"In contrast, 1pM cortisone or dexamethasone decreased p-PKB (Ser473) to PKB ratio, increased p-IkappaBalpha to IkappaBalpha ratio, and increased nuclear NF-kappaB subunit p50."