IndraLab

Statements

DHB decreases the amount of KCNH2. 6 / 6
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"In short, our date demonstrated that DHB acutely blocked hERG channels and poteintially decreased hERG plasma membrane expression through two pathways involving disruption of forward trafficking of immature hERG channels and enhanced degradation of mature hERG channels."
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"DHB may decrease hERG plasma membrane expression through two pathways involving disruption of forward trafficking of immature hERG channels and enhanced degradation of mature hERG channels."
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"DHB inhibited the hERG current concentration-dependently after instantaneous perfusion, accelerated channel inactivation by directly binding tyrosine (Tyr652) and phenylalanine (Phe656), and decreased mature (155-kDa) and simultaneously increased immature (135-kDa) hERG expression, respectively."
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"DHB decreases hERG plasma membrane expression through two pathways involving the disruption of the forward trafficking of immature hERG channels and the enhancement of the degradation of the mature hERG channels."
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"DHB reduces mature hERG protein level by inhibiting its trafficking."
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"Further, we suggested that DHB decreased hERG plasma membrane expression through two pathways : the disruption of the forward trafficking of immature hERG channels and the enhancement of the degradation of the mature hERG channels."
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