IndraLab

Statements

DNMT3A inhibits KCNA2. 4 / 4
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"DNMT3a represses Kcna2 in DRG neurons."
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"DNMT3a overexpression markedly reduced Kcna2 promoter activity, which could be blocked when both −457 and −444 CpG sites were deleted (Supplementary Fig. 4b)."
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"Given that SNL did not alter the basal expression of another de novo methyltransferase DNMT3b, or any TETs (that lead to oxidation of methylated DNA and to demethylation) in the injured DRG, our findings suggest a specific contribution of DNMT3a-triggered DNA methylation at these two sites of the Kcna2 promoter to nerve injury-induced Kcna2 gene silencing in the injured DRG."
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"Whether the SNL-induced increase in DNMT3a-triggered DNA methylation occurs at other CpG sites within the Kcna2 gene regions that were not studied is unknown, but DNMT3a overexpression significantly reduced Kcna2 promoter activity, which could be rescued when both −457 and −444 CpG sites were deleted."
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