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BAP1 inhibits regulation of cell cycle. 3 / 3
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"Considering the changes from asynchronous cells may be the indirect effect due to cell cycle arrest caused by BAP1 loss, we synchronized cells at the G1/S boundary and found that BAP1 depletion also r[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The BAP1 gene encodes BRCA1-associated protein 1, which suppresses tumors by promoting the activity of the Hippo tumor suppressor pathway[20]."
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"Their studies revealed differential expression of the cancer-related lncRNAs Malat1, Neat1, H19, Meg3, and their associated miRNA-target pairs, regulating various hallmarks of tumorigenesis such as cell cycle and p53 signaling.BRCA1-Associated Protein 1 (BAP1) is known to enhance BRCA1 tumor suppressor potential and its inactivation is associated with various cancers, in particular clear-cell renal cell carcinoma (ccRCC)."
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