IndraLab

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Melatonin inhibits MYD88. 9 / 9
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"Therefore, we only verified the relationship between how MT inhibits inflammation and the TLR4/MyD88/NF-κB signaling pathway, demonstrating that MT can down-regulate TLR4, MyD88, and NF-κB expression."
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"In LPS-stimulated RAW264.7 cells , melatonin attenuated the expression of MyD88 and the activation of NF-kappaB , and also inhibited TLR4-mediated AKT phosphorylation and attenuated the elevation of IRF3 , which was involved in TLR4-mediated TRIF-dependent signaling pathway10 ."
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"In addition, melatonin decreased TNBS induced up-regulation of TLR4, MyD88, and NF-kappaB p65, and increased down-regulation of I-kappaB proteins."
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"A similar observation was made in a colitis study in rats, where melatonin reduced the up-regulation of TLR4, MyD88, and NF-κB induced by trinitrobenzenesulfonic acid [31]."
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"Melatonin treatment could effectively downregulates TLR4 and its downstream targets, including myeloid differentiation factor 88 (MyD88), NF-κB, inhibitor of NF-κB alpha (IkBα), TLR-associated activat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, melatonin can abrogate the MyD88‐independent TLR4 pathway and reduce the activation of TRIF and IRF3 [222, 223, 224]."
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"Melatonin therapy attenuates the TLR4 signaling pathway in a MyD88- and TRIF dependent manner, dampening the inflammatory process induced by OC in a preclinical model of ovarian carcinogenesis."
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"Additionally, as widely reviewed in [XREF_BIBR], melatonin is able to inhibit NF-kappaB upstream genes (Myd88 and Trif)."
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"This may also be the main reason why MT inhibits TLR4, MyD88, and NF-κB in this study."
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