IndraLab

Statements

Melatonin inhibits MYD88. 5 / 5
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eidos
"In LPS-stimulated RAW264.7 cells , melatonin attenuated the expression of MyD88 and the activation of NF-kappaB , and also inhibited TLR4-mediated AKT phosphorylation and attenuated the elevation of IRF3 , which was involved in TLR4-mediated TRIF-dependent signaling pathway10 ."
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"Melatonin therapy attenuates the TLR4 signaling pathway in a MyD88- and TRIF dependent manner, dampening the inflammatory process induced by OC in a preclinical model of ovarian carcinogenesis."
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"Moreover, our result indicated that melatonin disrupted the formation of TLR4, MyD88, MD2, and CD14 complex."
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"Additionally, as widely reviewed in [XREF_BIBR], melatonin is able to inhibit NF-kappaB upstream genes (Myd88 and Trif)."
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"In addition, melatonin decreased TNBS induced up-regulation of TLR4, MyD88, and NF-kappaB p65, and increased down-regulation of I-kappaB proteins."
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