IndraLab

Statements

CDK5 phosphorylates KCNB1. 6 / 7
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rlimsp
"Recently, cyclin-dependent kinase 5 (Cdk5) was shown to phosphorylate Kv2.1, with pharmacological Cdk5 inhibition being sufficient to decluster channels."
24647953
sparser
"CDK5 phosphorylation of Kv2.1 produces hyperpolarizing shifts in voltage-dependent activation, while AMPK phosphorylation links cellular energy status to neuronal excitability through voltage-dependent shifts in both activation and inactivation [ xref , xref ] ( xref )."
41151066
rlimsp
"Activity-dependent phosphorylation of neuronal Kv2.1 potassium channels by CDK5."
21712386
rlimsp
"Here, we show that cyclin-dependent kinase 5 (CDK5), a Pro-directed Ser/Thr protein kinase, directly phosphorylates Kv2.1, and determines the constitutive level of Kv2.1 phosphorylation, the rapid increase in Kv2.1 phosphorylation upon acute blockade of neuronal activity, and the recovery of Kv2.1 phosphorylation after stimulus-induced dephosphorylation."
21712386
sparser
"Kv2.1 is directly phosphorylated by CDK5, which maintains Kv2.1 at constitutively highly phosphorylated state in neurons ( xref )."
41241096
reach
"CDK5-dependent phosphorylation of K V 2.1 drives NPC1-dependent increases in Ca V 1.2 clustering in isolated neurons."
37507375