IndraLab

Statements


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eidos
"It has been reported that USP10 mediates cancer progression via stabilizing some substrates , such as p53 , STRT6 , AMPK , FLT3 and androgen receptor [ 20-24 ] ."

reach
"In addition to USP10 controlling cell proliferation, a study from the Ouchida group revealed that USP10 promotes tumor migration or invasion."

reach
"We next found that USP10 coordinately promotes tumor progression with G3BP1."

reach
"For instance, USP10 promotes tumor metastasis through deubiquitination and stabilization of Smad4 in advanced HCC [8]."

reach
"Our studies suggest that USP10 by protecting pancreatic cancer cells from ER stress may support tumor progression."

eidos
"On the other hand , USP10 , a p53 deubiquitinase , serves as a positive regulator of p53 ; inhibition of USP10 could suppress cancer by degrading oncogenic p53 mutants ( Figure 2b ) [ 32 ] ."