IndraLab

Statements

USP10 activates Neoplasms. 6 / 7
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"It has been reported that USP10 mediates cancer progression via stabilizing some substrates , such as p53 , STRT6 , AMPK , FLT3 and androgen receptor [ 20-24 ] ."
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"In addition to USP10 controlling cell proliferation, a study from the Ouchida group revealed that USP10 promotes tumor migration or invasion."
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"We next found that USP10 coordinately promotes tumor progression with G3BP1."
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"For instance, USP10 promotes tumor metastasis through deubiquitination and stabilization of Smad4 in advanced HCC [8]."
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"Our studies suggest that USP10 by protecting pancreatic cancer cells from ER stress may support tumor progression."
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"On the other hand , USP10 , a p53 deubiquitinase , serves as a positive regulator of p53 ; inhibition of USP10 could suppress cancer by degrading oncogenic p53 mutants ( Figure 2b ) [ 32 ] ."
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