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USP10 activates Neoplasms. 16 / 17
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"Importantly, knockdown of USP10 blocked the growth rate of tumors in mice (Figure 5A)."
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"Our studies suggest that USP10 by protecting pancreatic cancer cells from ER stress may support tumor progression."
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"A particularly important observation was that knockdown of USP10 in wild-type p53 cell lines promoted proliferation and metastasis, suggesting that USP10 could inhibited tumor development under the background of wild-type p53."
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"Deleting USP10 significantly suppressed tumor growth in preclinical models."
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"On the other hand , USP10 , a p53 deubiquitinase , serves as a positive regulator of p53 ; inhibition of USP10 could suppress cancer by degrading oncogenic p53 mutants ( Figure 2b ) [ 32 ] ."
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"On the other hand, USP10 overexpression promoted YAP1 expression, improved EMT, and simultaneously increased distant tumor metastasis."
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"Collectively, our data suggested that USP10 depended on BAZ1A to potentiate HNSCC self-renewal capacity and tumor progression."
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"Furthermore, the inhibition of USP10 can inhibit the growth of imatinib-sensitive and -resistant CML cells, primary CML cells, and transplanted tumors in nude mice, which process depends on the functional state of SKP2."
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"Importantly, USP10 knockdown reduced the tumor dissemination in lung and liver tissues (Figure 5H,I)."
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"A recent study illustrated that USP10 may promote tumor growth by affecting immunity, but the exact mechanism is still unclear [48]."
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"It has been reported that USP10 mediates cancer progression via stabilizing some substrates , such as p53 , STRT6 , AMPK , FLT3 and androgen receptor [ 20-24 ] ."
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"However, other studies have reported that USP10 overexpression promotes tumor metastasis or proliferation in adult T cell leukemia, 40 glioblastoma multiforme, 41 chronic myeloid leukemia, 42 non‐small‐cell lung cancer, 43 and liver cancer."
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"In addition, we conducted the tumor xenograft assays to elucidate the in vivo roles of USP10 and found that USP10 overexpression remarkably enhanced tumor growth compared with those of tumors derived from the control cells (Fig. 2G and Fig. S1H)."
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"In addition to USP10 controlling cell proliferation, a study from the Ouchida group revealed that USP10 promotes tumor migration or invasion."
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"For instance, USP10 promotes tumor metastasis through deubiquitination and stabilization of Smad4 in advanced HCC [8]."
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"We next found that USP10 coordinately promotes tumor progression with G3BP1."
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