IndraLab

Statements

FIH binds OTUB1. 3 / 3
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"Interestingly, this interaction was greatly reduced with OTUB1 N22A, indicating a key role for this residue in the interaction between FIH and OTUB1 (Figs XREF_FIG and XREF_SUPPLEMENTARY)."
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"Initially, we checked the effect of hypoxia on the formation of FIH and OTUB1 heterodimers."
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"Collectively, these data suggest that OTUB1 facilitates hypoxia adaptation, which might benefit cancer progression.In order to determine whether the formation of FIH and OTUB1 heterodimers could affect OTUB1’s regulation on hypoxia signaling, we used FG4592 to stabilize HIF-1α under normoxia."
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