IndraLab

Statements

USP4 activates cell differentiation. 5 / 5
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"19 A recent study has demonstrated that USP4 could promote osteoblast differentiation via Activation of Wnt and beta-catenin signalling by inducing Runx2."
33434305
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"Conversely, deubiquitination of the K48 linked polyubiquitination of RORgammat by the deubiquitinase ubiquitinspecific protease USP4 stabilizes RORgammat and promotes its activation of Th17 associated genes, whereas inhibition of USP4 activity diminishes Th17 differentiation."
31386594
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"USP4 can target the TGF-β receptor for deubiquitination and enhance the activation of the TGF-β/BMP signaling pathway to promote the proliferation and differentiation of MSCs (69)."
38940355
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"USP4, USP15 and USP17 stabilize RORγt, and promote Th17 cell differentiation and function."
31078284
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"Inhibition of the catalytic activity of USP4 with vialinin A, an inhibitor of USP4 isolated from the Chinese mushroom, impairs Th17 differentiation, suggesting that USP4 promotes Th17 differentiation."
31078284