IndraLab

Statements

Trazodone inhibits KCNH2. 9 / 12
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"Trazodone block of HERG channels was state dependent."
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"The precise mechanism remains unclear; however, the prevailing explanation is that trazodone overdose inhibits cardiac HERG potassium channels, leading to prolonged repolarization of cardiomyocytes, which increases the risk of cardiac arrhythmias ."
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"Inhibition of cardiac HERG potassium channels by the atypical antidepressant trazodone."
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"Trazodone inhibited HERG currents in a dose dependent manner with an IC50 of 2.9 microM in HEK cells and 13.2 microM in Xenopus oocytes."
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"In summary, the atypical antidepressant trazodone blocks cardiac HERG channels at concentrations that are probably relevant in vivo, particularly in overdosage."
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"However, trazodone blocks hERG channels at clinically relevant concentrations and therefore increases the QT duration [4142]."
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"A recent study demonstrated that trazodone inhibits hERG (human ether-á-go-go-related gene) channel current in a concentration dependent manner ( Zitron et al., 2004 )."
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"Both cisapride and E-4031 (data not shown) were included as positive controls.As shown in Fig. 1 , with superimposition of typical hERG voltage clamp current records acquired after equilibration with [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The potential clinical significance of the concentrations at which trazodone inhibits hERG channel current is discussed below and presented in Table 1 ."
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