IndraLab

Statements

Trazodone inhibits KCNH2. 8 / 8
2 | 6
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"Trazodone inhibited HERG currents in a dose dependent manner with an IC50 of 2.9 microM in HEK cells and 13.2 microM in Xenopus oocytes."
15322737
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"Inhibition of cardiac HERG potassium channels by the atypical antidepressant trazodone."
15322737
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"In summary, the atypical antidepressant trazodone blocks cardiac HERG channels at concentrations that are probably relevant in vivo, particularly in overdosage."
15322737
ctd
No evidence text available
28551711
ctd
No evidence text available
15740727
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"However, trazodone blocks hERG channels at clinically relevant concentrations and therefore increases the QT duration [4142]."
29372020
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"Trazodone block of HERG channels was state dependent."
15322737
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"Trazodone inhibited hERG channel current in a concentration dependent manner with an IC50 of 0.69 microM."
15740727