IndraLab

Statements

COPS6 inhibits FASN. 2 / 2
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"Wei et al[36] reported that COP9 signalosome subunit 6 (CSN6) and the tumor suppressor F-box and WD repeat domain-containing 7 (FBXW7β) prevented the degradation of FASN; as a result, the CSN6-FASN axis eventually promoted lipogenesis and tumor growth."
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reach
"We further showed that CSN6 KD accelerates FASN protein turnover (Fig. 2g), and that overexpressing CSN6 leads to reduced turnover rate of FASN (Fig. 2h)."
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