IndraLab

Statements

OTUB1 activates FOXM1. 7 / 11
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"Mechanistically , knockdown of OTUB1 down-regulated FOXM1 expression by promoting its ubiquitination ."
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"We found that LINC00857 acts as a protein scaffold by promoting the interaction between OTU domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) and FOXM1, which inhibited FOXM1 degradation [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The fact that OTUB1 specifically targets FOXM1 also supports the fact that FOXM1 is ubiquitinated by K48-linkage chains."
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"OTUB1 enhances FOXM1 stability in response to epirubicin treatment."
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"Our data show that WT OTUB1, but not the OTUB1 (C91S) catalytic dead mutant, can enhance the stability of FOXM1 in response to epirubicin in MCF-7 cells, suggesting that the deubiquitinase activity is required for the degradation of FOXM1."
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"This finding was interesting as OTUB1 inhibits the degradation of FOXM1 transcription factor, typically upregulated and overexpressed in aggressive therapy resistant breast cancer."
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"OTUB1 positively regulates FOXM1, a transcription factor that promotes Snail transcription."
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