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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

FBXL3 decreases the amount of ATXN3. 2 / 2

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"ATXN3 transcript levels, although variable across experiments, were actually higher when FBXL3 was overexpressed, with or without knockdown of CUL1 (XREF_SUPPLEMENTARY), indicating that the observed FBXL3 mediated reduction of ATXN3 levels occurs at the protein rather than transcriptional level, as expected."

31783119

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"Indeed, exogenous FBXL3 in SCA3 NPCs reduced the levels of both wild-type and pathogenic ATXN3 in a SCF dependent manner."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...