IndraLab

Statements

FBXL3 decreases the amount of ATXN3. 2 / 2
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"ATXN3 transcript levels, although variable across experiments, were actually higher when FBXL3 was overexpressed, with or without knockdown of CUL1 (XREF_SUPPLEMENTARY), indicating that the observed FBXL3 mediated reduction of ATXN3 levels occurs at the protein rather than transcriptional level, as expected."
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"Indeed, exogenous FBXL3 in SCA3 NPCs reduced the levels of both wild-type and pathogenic ATXN3 in a SCF dependent manner."
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