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USP10 deubiquitinates MDM2. 3 / 3

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"USP10 (a cytosolic deubiquitinating enzyme) with an affinity for p53 reverses Mdm2-mediated ubiquitination, cytoplasmatic degradation, and nuclear export and impacts the transcriptional activity of p53 (Sun and Dai, 2014)."

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"Another DUB, USP10 deubiquitinates p53, but not MDM2 or MDMX."

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"Thus, USP10 is the DUB that deubiquitinates and opposes the action of the E3 ligase Mdm2."

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INDRA sources:

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USP10 deubiquitinates MDM2. 3 / 3

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