IndraLab

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GSK3 phosphorylates USP27X. 4 / 4
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"For example, glycogen synthase kinase 3 beta (GSK3β) can directly bind to and phosphorylate USP27X, thereby enhancing the interaction between USP27X and CBX2 (Xing et al. 2023)."
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"These findings suggest that GSK3β-mediated phosphorylation of USP27X is indispensable for its binding and deubiquitination with CBX2."
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"Additionally, we have discovered a direct interaction between GSK3β and USP27X, where GSK3β phosphorylates USP27X to enhance its affinity for CBX2 and further stabilize CBX2 protein levels."
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"Our study also elucidates the involvement of GSK3β in modulating the GSK3β-USP27X-CBX2 axis, revealing that GSK3β can directly interact with and phosphorylate USP27X, thereby enhancing its binding affinity for CBX2."
38030604