IndraLab

Statements

USP18 is ubiquitinated. 13 / 13
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"SKP-Cullin-F-box protein (SCF SKP2 ) accelerates USP18 ubiquitination, thereby leading to its proteasomal degradation."
36319753
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"However, sorafenib treatment significantly decreased the ubiquitination and degradation of USP18 (Fig. xref )."
40514377
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"SKP (S-phase kinase-associated protein)-Cullin-F-box protein (SCF SKP2 ) facilitates USP18 ubiquitination and subsequent degradation by the proteasomes."
32957626
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"In this study, we demonstrate that UBP43 is ubiquitinated in vivo and accumulates in cells treated with proteasome inhibitors."
15342634
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"Current models suggest that ISG15 antagonizes the SKP2‐mediated ubiquitination and degradation of USP18, promoting its functions [ xref , xref , xref ]."
39931755
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"Furthermore, knockdown of ISG15 enhances the ubiquitination of USP18, leading to a reduction in the accumulation of USP18 in sorafenib-treated HCC cells (Fig. xref and Supplementary Fig. xref )."
40514377
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"The non-covalent interactions of ISG15 and USP18 prevent the ubiquitination of USP18 by S-phase kinase-associated protein two and stabilize the downregulation of the IFN signaling pathway by USP18 ( xref ; xref )."
34901029
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"Skp2 promotes the ubiquitination of UBP43 and subsequent degradation by the proteasomes, suggesting that the SCFSkp2 may be involved in the regulation of type I IFN signaling by controlling the stability of UBP43."
20153823
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"Given that knockdown of USP18 leads to increased K48-linked ubiquitination of proteins, we speculated that USP18 K48-linked ubiquitination of Notch1 and thus stabilizes Notch1."
33051403
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"The skp2 protein, a substrate recognition factor for SCF-E3 ubiquitin ligase complexes, promoted USP18 ubiquitination and degradation [82] ."
17961905
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"Moreover, we investigated the potential relationships between USP18 ubiquitination and Sanil1 in USP18 over-expressed DLD1 cells."
32742193
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"Yet, engineered gain of USP18 expression downregulated total ubiquitination and UBE1 levels ( xref ), providing a mechanistic basis through which the DUB USP18 affects UCP1 expression."
33380466
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"S-phase kinase-associated protein 2 (SKP2) is an E3 ligase that mediates the ubiquitination of USP18 and subsequently promotes its proteasomal degradation [ xref , xref ]."
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