IndraLab

Statements

SMAD binds USP15. 3 / 3
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"Despite reports that USP15 interacts with SMADs 2 and 3 [ xref , xref ], we failed to detect USP15 interacting with any of the SMAD proteins (see the electronic supplementary material, figure S2)."
22773947
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"A previous study has shown that USP15 interacts with receptor-phosphorylated SMAD proteins (R-SMADs) and deubiquitinates transforming growth factor-β (TGF-β) receptor 1 (TBR1), thereby promoting protein stability ( xref )."
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"To detect interactions between USP15 and FLAG-tagged SMADs, endogenous USP15 was immunoprecipitated from HEK293 cell extracts transfected with either empty vector control or FLAG-tagged SMADs 1, 3, 4, 6 and 7 ( xref b )."
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