IndraLab
Statements
sparser
"We further used ChIP assays and found that DNMT3a binds to two regions (−663/−389 bp and −491/−199 bp) of the Kcna2 gene promoter, as demonstrated by the amplification of only these two regions (out of 7 regions from –663 to +928 bp) from the complexes immunoprecipitated with DNMT3a antibody in nuclear fractions from sham DRG ( xref )."
sparser
"How DNMT3a specifically targets Kcna2 is unknown, but DNMT3a participation in nerve injury-induced DRG Kcna2 silencing may be related to the increased binding of DNMT3a to the Kcna2 gene promoter region (−663/−199) and associated with an elevation in DNA methylation levels within this region after SNL."