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Auranofin inhibits NLRP3. 19 / 19
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"Previous studies showed that the anti-rheumatic agent auranofin inhibits the NLRP3 inflammasome; thus, this study evaluates the antifibrotic effect of auranofin in vivo and explores the underlying molecular mechanism."
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"Auranofin, as a thioredoxin reductase 1 (TrxR1) and TrxR2 inhibitor, can activate the NLRP3 inflammasome to release proinflammatory caspase-1 and cause pyroptotic cell death as measured by LDH leakage."
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"Another study of mice with CCl 4 -induced hepatic fibrosis showed that the anti-rheumatic agent auranofin effectively inhibits the activation of NLRP3 inflammasomes in HSCs, bone marrow-derived macrop[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Auranofin suppressed the activation of the P. acnes induced NLRP3 inflammasome in macrophages and sebaceous gland cells in a dose dependent manner but not in NLRP3- or caspase-1-deficient macrophages."
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"For instance, auranofin inhibits the differentiation and maturation of NLRP3 and pro-IL-1β by inhibiting NF-ĸB activation, and inhibitors such as FC11A-2 inhibit the expression of NLRP3, ASC, caspase-1 and pro-IL-1β."
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"In a previous study, we found that auranofin prevents liver fibrosis by inhibiting the NLRP3 inflammasome in macrophages and fibrotic liver tissues (Kim et al. 2021)."
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"A study also showed that the gold salt auranofin could inhibit the NLRP3 inflammasome in mice, suggesting anti-acne effects [269]."
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"Another thioredoxin reductase inhibitor auranofin was reported to impair TLR4-dependent induction of the inflammasome receptor NLRP3 in macrophages [ 44 ]."
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"In addition, auranofin suppressed the induction of the macrophage inflammasome receptor NLRP3, thereby attenuating inflammasome mediated generation of bioactive IL-1beta as well as induction of cell d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Auranofin inhibits the NLRP3 inflammasome by blocking system x activity (Kim et al. 2021)."
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"Similar to auranofin, aurocyanide significantly inhibited NLRP3 inflammasome activity in a concentration-dependent manner (Fig. 2C)."
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"Auranofin, an anti-rheumatic gold compound, can attenuate the activation of NLRP3 inflammasome in macrophages, sebocytes and animals."
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"Auranofin potently inhibits activation of the NLRP3 inflammasome in BMDM and kupffer cell."
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"In this study, we investigated whether auranofin, an anti-rheumatoid arthritis agent, inhibited NLRP3 inflammasome activation, thereby effectively treating acne vulgaris."
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"Auranofin suppressed NLRP3 inflammasome activation induced by Propionibacterium acnes, reducing the production of IL-1beta in primary mouse macrophages and human sebocytes."
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"These results show that auranofin inhibits the NLRP3 inflammasome, the activation of which is associated with acne symptoms."
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"Auranofin suppresses NLRP3 inflammasome activation in macrophages and sebocytes."
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"To investigate whether auranofin inhibited activation of the NLRP3 inflammasome in macrophages, mouse bone marrow derived macrophages were stimulated with NLRP3 inflammasome activators, ATP or nigericin, in the presence or absence of auranofin."
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"Inhibition of TrxR1 activity by the FDA-approved drug auranofin inhibits Nlrp3 activation in cultured macrophages and ameliorates hepatic injury in murine models of fibrosis.7–9,20 The objective of this study was to examine the effect of hepatocyte-specific deletion of TrxR1 (TrxR1 ) on hepatic inflammation, inflammasome activation, and injury during acute BDL-induced cholestatic injury."
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