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Auranofin inhibits NLRP3. 12 / 12
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"These results show that auranofin inhibits the NLRP3 inflammasome, the activation of which is associated with acne symptoms."
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"In this study, we investigated whether auranofin, an anti-rheumatoid arthritis agent, inhibited NLRP3 inflammasome activation, thereby effectively treating acne vulgaris."
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"Previous studies showed that the anti-rheumatic agent auranofin inhibits the NLRP3 inflammasome; thus, this study evaluates the antifibrotic effect of auranofin in vivo and explores the underlying molecular mechanism."
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"Auranofin potently inhibits activation of the NLRP3 inflammasome in BMDM and kupffer cell."
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"These results show that auranofin inhibits the NLRP3 inflammasome, the activation of which is associated with acne symptoms."
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"Auranofin suppressed the activation of the P. acnes induced NLRP3 inflammasome in macrophages and sebaceous gland cells in a dose dependent manner but not in NLRP3- or caspase-1-deficient macrophages."
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"In this study, we investigated whether auranofin, an anti-rheumatoid arthritis agent, inhibited NLRP3 inflammasome activation, thereby effectively treating acne vulgaris."
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"Auranofin suppressed NLRP3 inflammasome activation induced by Propionibacterium acnes, reducing the production of IL-1beta in primary mouse macrophages and human sebocytes."
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"To investigate whether auranofin inhibited activation of the NLRP3 inflammasome in macrophages, mouse bone marrow derived macrophages were stimulated with NLRP3 inflammasome activators, ATP or nigericin, in the presence or absence of auranofin."
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"Auranofin suppresses NLRP3 inflammasome activation in macrophages and sebocytes."
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"Auranofin suppressed NLRP3 inflammasome activation induced by Propionibacterium acnes, reducing the production of IL-1beta in primary mouse macrophages and human sebocytes."
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"In addition, auranofin suppressed the induction of the macrophage inflammasome receptor NLRP3, thereby attenuating inflammasome mediated generation of bioactive IL-1beta as well as induction of cell d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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