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USP22 activates Neoplasm Invasiveness. 52 / 52
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"In addition, we present evidence that USP22 promotes Bel/Fu cell growth, migration, invasion, EMT and chemoresistance."
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"USP22 plays as an interactor with LINC01426 and activates the hedgehog pathway to promote the invasion and metastasis in lung adenocarcinoma via stabilizing SHH protein [ 48 ]."
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"In further functional analysis, ADAM9 deletion abolished USP22-triggered suppression in proliferation ( Fig. 5 B–D), promotion in apoptosis ( Fig. 5 E), and weakness in invasion and migration abilitie[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Our results indicate that USP22 promotes cell proliferation, migration, invasion, and cell cycle transition, while inhibiting apoptosis in gastric cancer cells."
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"USP22 knockdown significantly decreased in vitro survival, proliferation, migration, and invasiveness of GC cells compared with the controls."
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"For example, USP22 mentioned above promotes LUAD cell invasion and migration62."
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"In this study, we show that USP22 knockdown significantly decreases migration and invasiveness of GC cells."
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"USP22 silencing inhibits the proliferation, invasion, and EMT of OS cells in vitro ."
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"These results suggest that while USP22 promotes cell migration and invasion, loss of USP22 sensitizes EGFR mutant NSCLC cells to erlotinib in vitro."
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"USP22 promotes cell proliferation, migration, and invasion in multiple cancers, including glioma, lung adenocarcinoma, thyroid carcinoma, colorectal cancer, and gastric cancer [27–31]."
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"These results indicate that inhibition of USP22 expression can suppress Sao-2 cell migration and invasion."
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"These results indicate that USP22 increases CRC cell migration and invasion abilities by promoting EMT."
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"Silencing USP22 in Bel/Fu cells inhibited proliferation, migration, invasion and chemoresistance both in vitro and in vivo."
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"Consistent with these findings, our data demonstrate that USP22 promotes gastric cancer cell proliferation, migration, and invasion in vitro and enhances tumor growth in vivo."
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"In lung adenocarcinoma cells, USP22 was implicated to promote cell invasion by the induction of EMT."
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"USP22 is also upregulated in many cancer cells and activates the proliferation, migration, and invasion of gastric cancer, colorectal cancer, and breast cancer XREF_BIBR - XREF_BIBR."
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"USP22 increases CRC cell migration and invasion by inducing EMT."
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"USP22 silencing suppresses in vitro GC cell migration and invasiveness."
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"USP22 knockdown reduces T cell-dependent tumor metastasis, increases the immunogenicity of tumors, increases the lymphatic invasion of tumors and natural killer cell activity [ 82 ], and enhances anti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP22 inhibition, PI3K inhibitor (GDC‐0941), Akt inhibitor (MK‐2206), and mTOR inhibitor (AZD‐8055) strongly inhibited melanoma invasion in melanoma cells (Figure 4F,G)."
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"USP22 knockdown suppressed migration and invasion of HCC chemoresistant cells."
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"Silencing USP22 decreased the migration and invasion of Bel/Fu cells, and combination with 5-Fu further decreased the rate of migration and number of invading cells."
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"Upregulation of USP22 increases the progression and invasion of tumor cells and is associated with unfavorable prognosis [148 – 151] ."
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"Furthermore, USP22 promotes the proliferation, migration, and invasion of pancreatic, breast, gastric, and colorectal cancers and is associated with poor prognosis [56-59]."
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"P-p38 MAPK inhibited the expression of USP22, and overexpression of USP22 eliminated the inhibitory roles of P-p38 MAPK on tumor growth, as well as cell proliferation, migration and invasion."
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"USP22 silencing suppresses the migration and invasion of ATC cells in vitro."
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"Similarly, knockdown of USP22 significantly reduced invasion of CAL-62 and 8505C cells in matrigel invasion assays."
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"Taken together, these results indicate that USP22 increases cell migration and invasion by inducing EMT by binding to the promoter of AP4 to activate its transcription."
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"Therefore, USP22 silencing impairs ATC cell migration and invasion by ablating EMT."
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"USP22 downregulation inhibited OS cell proliferation , invasion , and epithelial-mesenchymal transition ( EMT ) in vitro ."
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"USP22 knockdown decreases in vitro proliferation, migration and invasiveness of GC cells."
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"Previous reports showed that USP22, another ubiquitin specific protease, promotes tumor invasion and metastasis 33, 34."
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"These findings indicate that USP22 promotes CRC invasion and metastasis by inducing EMT via AP4 activation."
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"Some studies also revealed that USP22 can increase the invasion behavior of cancer cells by inducing EMT ( Hu et al., 2015 )."
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"Our data demonstrate that USP22 deletion inhibits the migration and invasion of HCC cells (Fig. 5F, G and Supplementary Fig. S6D)."
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"USP22 can promote lung cancer cell invasion via epithelial-mesenchymal transition (EMT), which participates in the metastasis of primary tumors by activating TGF-beta1 [XREF_BIBR]."
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"We drew a conclusion that USP22 could increase the abilities of proliferation, migration and invasion of glioma cells, and promote the growth and development of glioma."
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"We also examined the effect of the Akt inhibitor (MK-2206) on OS cell invasion mediated by downregulation of USP22."
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"Knockdown of USP22 in drug-resistant HCC cells could reduce the invasion, migration and stemness of cells."
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"These results suggest that USP22 promotes in vitro GC cell migration and invasion."
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"We found that USP22 knockdown could inhibit the glycolytic pathway in osteosarcoma cells, suppress cell proliferation, migration and invasion, and promote cancer cell apoptosis.Glycolysis is one of the major pathways for cells to generate energy by converting glucose into lactate and producing ATP (Lunt & Vander Heiden, 2011)."
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"USP22 and STAT3 co-depletion partly rescued the MMP9 proteolytic activity and invasion of SW480 cells, compared with that of STAT3 depletion alone."
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"Our results also demonstrated that USP22 can increase cell migration and invasion abilities via EMT induction."
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"USP22 promotes cell proliferation, migration, and invasion in gastric cancer cells."
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"Silencing USP22 in chemoresistant HCC Bel/Fu cells dramatically inhibited proliferation, migration, invasion and epithelial-mesenchymal transition in vitro; suppressed tumorigenic and metastatic capacities in vivo; and inhibited drug resistance related proteins (MDR1, LRP, MRP1)."
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"Compared with the corresponding negative control, USP22 overexpression significantly promoted cell proliferation, migration, and invasion in SGC7901 cells, whereas USP22 knockdown significantly inhibited these behaviors in AGS cells (Fig. 2b–d)."
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"Through measuring the proliferation, migration and invasion of SW480 and SW620 cells, we uncovered that USP22 knockdown could suppress the proliferation, migration and invasion of CRC cells, while USP22 overexpression had an opposite effect (Supplement Figure 2)."
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"USP22 overexpression enhances colon cancer migration and invasiveness by inducing EMT via activating AP4 (activating enhancer binding protein-4) transcription by binding to its promoter[54]."
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"We also suggested that downregulation of USP22 inhibited OS cell proliferation and invasion in vitro ."
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"USP22 promotes the invasion of NSCLC in a TFAP2A-dependent manner [11]."
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"USP22 knockdown reduces the invasiveness and metastasis of multiple cancers by downregulating pathways driven by the oncoprotein, BMI-1 [27, 29, 33]."
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"Subsequent experiments showed that USP22 knockdown resulting from up-regulation of miR-30e-5p could inhibit proliferation, invasion, migration, and EMT in 5-8F cells."
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