IndraLab

Statements

USP22 activates Neoplasm Invasiveness. 40 / 40
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"In lung adenocarcinoma cells, USP22 was implicated to promote cell invasion by the induction of EMT."
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"USP22 and STAT3 co-depletion partly rescued the MMP9 proteolytic activity and invasion of SW480 cells, compared with that of STAT3 depletion alone."
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"USP22 can promote lung cancer cell invasion via epithelial-mesenchymal transition (EMT), which participates in the metastasis of primary tumors by activating TGF-beta1 [XREF_BIBR]."
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"USP22 silencing suppresses in vitro GC cell migration and invasiveness."
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"We drew a conclusion that USP22 could increase the abilities of proliferation, migration and invasion of glioma cells, and promote the growth and development of glioma."
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"Through measuring the proliferation, migration and invasion of SW480 and SW620 cells, we uncovered that USP22 knockdown could suppress the proliferation, migration and invasion of CRC cells, while USP22 overexpression had an opposite effect (Supplement Figure 2)."
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"These results indicate that USP22 increases CRC cell migration and invasion abilities by promoting EMT."
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"Silencing USP22 decreased the migration and invasion of Bel/Fu cells, and combination with 5-Fu further decreased the rate of migration and number of invading cells."
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"Taken together, these results indicate that USP22 increases cell migration and invasion by inducing EMT by binding to the promoter of AP4 to activate its transcription."
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"For example, USP22 mentioned above promotes LUAD cell invasion and migration62."
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"Previous reports showed that USP22, another ubiquitin specific protease, promotes tumor invasion and metastasis 33, 34."
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"We also suggested that downregulation of USP22 inhibited OS cell proliferation and invasion in vitro ."
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"USP22 knockdown significantly decreased in vitro survival, proliferation, migration, and invasiveness of GC cells compared with the controls."
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"Our data indicated that USP22 may promote lung adenocarcinoma cell invasion by the induction of EMT."
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"USP22 knockdown suppressed migration and invasion of HCC chemoresistant cells."
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"Similarly, knockdown of USP22 significantly reduced invasion of CAL-62 and 8505C cells in matrigel invasion assays."
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"In this study, we show that USP22 knockdown significantly decreases migration and invasiveness of GC cells."
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"Therefore, USP22 silencing impairs ATC cell migration and invasion by ablating EMT."
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"USP22 downregulation inhibited OS cell proliferation , invasion , and epithelial-mesenchymal transition ( EMT ) in vitro ."
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"These findings indicate that USP22 promotes CRC invasion and metastasis by inducing EMT via AP4 activation."
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"In addition, we present evidence that USP22 promotes Bel/Fu cell growth, migration, invasion, EMT and chemoresistance."
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"Subsequent experiments showed that USP22 knockdown resulting from up-regulation of miR-30e-5p could inhibit proliferation, invasion, migration, and EMT in 5-8F cells."
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"Here, we showed that USP22 promotes cell proliferation, migration and invasion, and contributes to resistance to EGFR-TKIs in EGFR mutant lung ADC cells."
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"Consistent with these findings, our data demonstrate that USP22 promotes gastric cancer cell proliferation, migration, and invasion in vitro and enhances tumor growth in vivo."
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"Compared with the corresponding negative control, USP22 overexpression significantly promoted cell proliferation, migration, and invasion in SGC7901 cells, whereas USP22 knockdown significantly inhibited these behaviors in AGS cells (Fig. 2b–d)."
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"These results suggest that while USP22 promotes cell migration and invasion, loss of USP22 sensitizes EGFR mutant NSCLC cells to erlotinib in vitro."
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"These results suggest that USP22 promotes in vitro GC cell migration and invasion."
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"USP22 promotes cell proliferation, migration, and invasion in multiple cancers, including glioma, lung adenocarcinoma, thyroid carcinoma, colorectal cancer, and gastric cancer [27–31]."
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"USP22 promotes cell proliferation, migration, and invasion in gastric cancer cells."
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"Silencing USP22 in chemoresistant HCC Bel/Fu cells dramatically inhibited proliferation, migration, invasion and epithelial-mesenchymal transition in vitro; suppressed tumorigenic and metastatic capacities in vivo; and inhibited drug resistance related proteins (MDR1, LRP, MRP1)."
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"USP22 knockdown decreases in vitro proliferation, migration and invasiveness of GC cells."
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"Our results indicate that USP22 promotes cell proliferation, migration, invasion, and cell cycle transition, while inhibiting apoptosis in gastric cancer cells."
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"USP22 knockdown reduces the invasiveness and metastasis of multiple cancers by downregulating pathways driven by the oncoprotein, BMI-1 [27, 29, 33]."
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"Our results also demonstrated that USP22 can increase cell migration and invasion abilities via EMT induction."
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"USP22 is also upregulated in many cancer cells and activates the proliferation, migration, and invasion of gastric cancer, colorectal cancer, and breast cancer XREF_BIBR - XREF_BIBR."
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"USP22 increases CRC cell migration and invasion by inducing EMT."
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"We also examined the effect of the Akt inhibitor (MK-2206) on OS cell invasion mediated by downregulation of USP22."
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"USP22 silencing suppresses the migration and invasion of ATC cells in vitro."
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"P-p38 MAPK inhibited the expression of USP22, and overexpression of USP22 eliminated the inhibitory roles of P-p38 MAPK on tumor growth, as well as cell proliferation, migration and invasion."
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"Silencing USP22 in Bel/Fu cells inhibited proliferation, migration, invasion and chemoresistance both in vitro and in vivo."
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