IndraLab

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USP25 increases the amount of FOXM1. 7 / 7
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"Then, the western blot assays indicated that knockdown of USP21 in nasopharyngeal carcinoma cells would inhibit FOXM1 expression, and overexpression of FOXM1 could reverse the cell proliferation ability, cell migration and invasion ability, and cell stemness profiles."
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"These results proved that USP21 promoted nasopharyngeal carcinoma progression through regulating FOXM1 expression."
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"In our study, the results showed that USP21 positively regulated FOXM1 expression, and overexpression of FOXM1 could reverse the cell proliferation ability, cell migration and invasion ability, and cell stemness profiles, suggesting that USP21 promoted nasopharyngeal carcinoma progression through regulating FOXM1 expression.In conclusion, this study demonstrated the mRNA and protein expression of USP21 was higher in nasopharyngeal carcinoma tissues or cell lines than normal tissue or normal nasopharyngeal epithelial cells, respectively."
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"Further research indicated that USP21 promoted nasopharyngeal carcinoma progression through regulating FOXM1 expression."
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"Therefore, our results indicated that USP21 promoted tumor growth and cancer cell stemness in nasopharyngeal carcinoma by regulating FOXM1 expression, which could pave the way for advanced therapeutic targets for NPC."
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"The stability of FOXM1 is regulated by deubiquitinating enzymes such as USP21, and inhibition of USP21 reduces FOXM1 levels and enhances the efficacy of paclitaxel in breast cancer."
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"IB analysis of cell lysates 48 h after transfection revealed that USP21 knockdown reproducibly reduced the level of endogenous FOXM1 (XREF_FIG)."
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