IndraLab

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Carnosol inhibits JUN. 2 / 2
| 2

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"Furthermore, carnosol was shown to inhibit ERK1/2, AKT, p38 and c-Jun N-terminal kinases (JNK), and led to the activation of the transcription factors NFκB and c-Jun."

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"Huang et al indicated that carnosol, the major compound of RO extract responsible for antioxidant and chemopreventive activity, downregulates nuclear factor-kappaB and c-Jun, thus suppressing the MMP9."