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OTUB1 activates Carcinogenesis. 8 / 10
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"Diego Iglesias-Gato et al. found that OTUB1 promotes the invasion and tumorigenesis of prostate cancer in vitro and in vivo by mediating Rho-A and P53 [ 47 ]."
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"They found that OTUB1 promotes the invasion and tumorigenesis of prostate cancer in vitro and in vivo by promoting Rho-A activation."
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"Previous research verified that OTUB1 promotes prostate cancer invasion in vitro and aggravates tumorigenesis in vivo via regulating RhoA activity and p53 expression ( Iglesias-Gato et al ., 2015 ) ."
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"OTUB1/NDUFS2 axis promotes pancreatic tumorigenesis through protecting against mitochondrial cell death."
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"OTUB1, a deubiquitinase that stabilizes SLC7A11, is consequently upregulated, inhibiting radiation-induced ferroptosis and promoting tumorigenesis [81] (Fig. 4B and Table 1)."
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"Therefore, OTUB1 promotes breast tumorigenesis in vivo and in vitro via blocking MYC protein degradation."
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"Through in vivo and in vitro experiments, we demonstrated that increased OTUB1 levels promote BLCA tumorigenesis and progression, along with conferring resistance to cisplatin treatment."
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"From the perspective of our findings, Han et al. [ 31 ] demonstrated that OTUB1 promoted breast tumorigenesis by deubiquitination of MYC Proto-Oncogene (MYC), which is similar to our findings."
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