A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

TSC2 inhibits RHEB. 10 / 153
1 | 6 47 99
reach
"Phosphorylation of TSC2 by AMPK can increase the GAP activity of TSC2, stabilize the TSC2 and TSC1 complex, and inactivate Rheb, resulting in the inactivation of mTORC1 and the initiation of autophagy XREF_BIBR."
reach
"Activation of IIS inhibits TSC1 and TSC2, a heterodimer that negatively regulates Rheb, an activator of the TOR complex."
sparser
"Indeed, in the scientific paper corpus we have used, this inhibition of Rheb by Tsc2 was not demonstrated."
sparser
"TSC2 inhibits Rheb, the upstream activator of mTORC1, while AKT and AMPK can activate or inhibit mTORC1 function by inhibiting or activating TSC2, respectively ( xref , xref )."
reach
"Akt activates mTORC1 through phosphorylation and inhibition of tumor-suppressor protein TSC2 (tuberin) thus releasing TSC2 inhibition of Rheb, which subsequently leads to mTORC1 activation [XREF_BIBR - XREF_BIBR]."
reach
"These phosphorylation events release TSC2 mediated inhibition of the GTPase Ras homolog enriched in brain (RHEB), thus allowing RHEB to activate mTORC1 [XREF_BIBR]."
reach
"TSC2 then inactivates Rheb, which impairs the interaction of mTOR with Rheb and Rag proteins."
reach
"Phosphorylation of TSC2 by AKT inactivates its Rheb GTPase activity, leading to activation of mTOR Complex 1 (mTORC1)."
sparser
"TSC2 inhibits RheB through its GAP activity and thus functions as negative regulator of mTORC1 signaling."
sparser
"This includes the inhibition of mTOR through the phosphorylation of the tumor suppressor TSC2, which inactivates Rheb and dampens mTOR activity."
TSC2 bound to TSC1 inhibits RHEB. 10 / 23
| 23
reach
"The TSC1 and TSC2 complex inactivates Rheb to inhibit mTOR signaling, which would lead to autophagy."
reach
"Typically, TSC1 and TSC2 form a complex, which inhibits Rheb (ras homologue expressed in brain), an activator of mTOR."
reach
"It has been shown that TSC1 and TSC2 complex inhibits Rheb GTPase activity, suppressing the mTORC1 pathway, a negative modulator of autophagy XREF_BIBR, XREF_BIBR."
reach
"On the other hand, it has been found that TORC1 is activated by the Ras family Rheb GTPase, which is negatively regulated by the Tsc1 and Tsc2 complex that acts as Rheb GTPase activating protein (GAP) [XREF_BIBR]."
reach
"The major downstream effector of LKB1 in response to energy stress is the TSC2 and TSC1 complex, which inhibits Rheb GTPase, a mTOR activator."
reach
"This makes the TSC1 and TSC2 complex unable to inactivate Rheb, promoting mTORC1 activation."
reach
"Phosphorylation of TSC2 inhibits the activity of the TSC1 and TSC2 complex, allowing the activation of Rheb and consequently mTORC1."
reach
"TSC2 phosphorylation by Akt represses GAP activity of the TSC1 and TSC2 complex, allowing Rheb to accumulate in a GTP bound state."
reach
"At the molecular level, both Tsc1 and Tsc2 protein products form hetero-dimers which inhibit the GTP binding protein RHEB (Ras homolog enriched in the brain)."
reach
"The hamartin and tuberin complex suppresses the activation of the small GTPase Rheb (ras homolog enriched in brain), through a GTPase activating domain near the C-terminus of tuberin."
Phosphorylated TSC2 inhibits RHEB. 1 / 1
| 1
reach
"Phosphorylation of TSC2 by AKT results in the activation of mTORC1, as the phosphorylated TSC2 no longer inhibits the Ras homolog enriched in brain (Rheb) protein that is critically required for mTORC1 functions 40."
TSC2 bound to TSC1 inhibits RHEB. 1 / 1
| 1
reach
"The phosphorylated TSC1 and TSC2 complex inactivates the Rheb GTP component needed for mTOR signaling."