IndraLab

Statements

TSC2 bound to TSC1 inhibits RHEB. 25 / 25
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"On the other hand, it has been found that TORC1 is activated by the Ras family Rheb GTPase, which is negatively regulated by the Tsc1 and Tsc2 complex that acts as Rheb GTPase activating protein (GAP) [XREF_BIBR]."
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"TSC1 and TSC2 form a complex that inhibits Rheb directed mTOR activation through a GTPase activating protein (GAP) domain in the TSC2 C terminus."
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"TSC2 phosphorylation by Akt represses GAP activity of the TSC1 and TSC2 complex, allowing Rheb to accumulate in a GTP bound state."
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"TSC2 phosphorylation by Akt represses GAP activity of the TSC1 and TSC2 complex, allowing Rheb to accumulate in a GTP bound state."
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"The tuberous sclerosis 1 (TSC1) and TSC2 form a complex that inactivates RHEB through its GAP (GTPase activating protein) activity, thereby suppressing mTORC1 activity."
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"The TSC1 and TSC2 complex normally suppresses the GTPase Rheb [XREF_BIBR]."
29789464
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"For example, the TSC1 and TSC2 complex inhibits mTOR functions by inactivating Rheb; Rheb binds and activates mTOR only when the former is in its GTP bound form."
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"TSC2 phosphorylation by Akt represses GAP activity of the TSC1 and TSC2 complex, allowing Rheb to accumulate in a GTP bound state."
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"The TSC1 and TSC2 complex inactivates Rheb to inhibit mTOR signaling, which would lead to autophagy."
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"The major downstream effector of LKB1 in response to energy stress is the TSC2 and TSC1 complex, which inhibits Rheb GTPase, a mTOR activator."
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"Phosphorylation of TSC2 inhibits the activity of the TSC1 and TSC2 complex, allowing the activation of Rheb and consequently mTORC1."
22239883
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"TSC2 phosphorylation by Akt represses GAP activity of the TSC1 and TSC2 complex, allowing Rheb to accumulate in a GTP bound state."
21422497
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"At the molecular level, both Tsc1 and Tsc2 protein products form hetero-dimers which inhibit the GTP binding protein RHEB (Ras homolog enriched in the brain)."
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"The hamartin and tuberin complex suppresses the activation of the small GTPase Rheb (ras homolog enriched in brain), through a GTPase activating domain near the C-terminus of tuberin."
19584242
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"We propose a model whereby Rheb promotes mTOR signaling when it is in an active GTP bound form, whereas the Tuberin and Hamartin heterodimer inhibits Rheb by converting it to an inactive GDP bound sta[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Rheb is negatively regulated by the GAP activity of the TSC1 and TSC2 complex 7."
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"The Tsc1 and Tsc2 complex inhibits the activity of Rheb via the GAP function of Tsc2."
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"In contrast, the three TSC2 GAP domain point mutants were unable to repress Rheb induced S6K1 activation, revealing that the GAP domain of Tuberin is critical for Tuberin 's ability to repress Rheb me[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12906785
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"It has been shown that TSC1 and TSC2 complex inhibits Rheb GTPase activity, suppressing the mTORC1 pathway, a negative modulator of autophagy XREF_BIBR, XREF_BIBR."
29622767
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"This makes the TSC1 and TSC2 complex unable to inactivate Rheb, promoting mTORC1 activation."
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"Typically, TSC1 and TSC2 form a complex, which inhibits Rheb (ras homologue expressed in brain), an activator of mTOR."
22619737
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"mTORC1 is activated by the Rheb GTPase, which, in turn, is inhibited by the TSC1 and TSC2 complex."
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"The TSC1 and TSC2 complex inhibits Rheb by exerting a strong GTPase activity toward it XREF_BIBR, XREF_BIBR."
22294621
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"Thus, according to this model, REDD1 activates the TSC1 and TSC2 complex, which inhibits Rheb, by functioning as a ' binding sink ' for 14-3-3."
19027299
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"Rheb is inhibited by the GAP activity of the TSC1 and TSC2 complex, which promotes the turnover of GTP to GDP."
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