IndraLab

Statements

AKT phosphorylates GATA1. 10 / 12
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"PI3K and AKT stimulates the phosphorylation and activation of GATA1 [XREF_BIBR], and activated GATA-1 upregulates its own gene expression through positive feedback regulation [XREF_BIBR]."
24677652
sparser
"Among its pleiotropic effects on erythroid cells, EPO-induced Akt activation promotes differentiation because Akt phosphorylates and activates GATA1 , providing a possible explanation for our observation that inhibition of Akt activity is associated with truncated differentiation."
32520308
sparser
"AKT phosphorylates GATA-1 in erythroid cells xref and K562 cells xref resulting in an increase in its DNA-binding affinity and enhanced transcriptional activity."
26035685
reach
"It has been reported that the activation of the PI3K/AKT pathway induces the phosphorylation of GATA-1 (Zhao et al., 2006)."
34603025
reach
"AKT has previously been shown to induce TIMP-1 expression by directly phosphorylating and activating GATA1."
23250987
reach
"Therefore, these results suggest that gastrodin stimulates the PI3K/AKT pathway and that activation of the PI3K/AKT pathway promotes USP4 expression by enhancing the phosphorylation of GATA1 in HepG2 cells."
34603025
reach
"AKT phosphorylates GATA-1 in erythroid cells XREF_BIBR and K562 cells XREF_BIBR resulting in an increase in its DNA binding affinity and enhanced transcriptional activity."
26035685
reach
"Here, we show that erythropoietin activates AKT, which phosphorylates GATA-1 at Ser310, thereby increasing GATA-1 affinity for FOG-1."
26680303
reach
"Of these, JAK2-STAT5 activates Bcl-xL to prevent apoptosis of erythroid progenitors, whereas Akt promotes differentiation by phosphorylating the essential erythroid transcription factor GATA1 and activating metabolic pathways via phosphorylation of the mTORC1 complex."
32520308
reach
"Among its pleiotropic effects on erythroid cells, EPO induced Akt activation promotes differentiation because Akt phosphorylates and activates GATA1, providing a possible explanation for our observation that inhibition of Akt activity is associated with truncated differentiation."
32520308
AKT phosphorylates GATA1 on S310. 10 / 11
1 1 | 3 5
sparser
"It has been reported that Akt directly phosphorylated GATA1 at serine 310 [ xref ], and PAK5 was in higher expression in breast cancer tissues than matched adjacent noncancerous tissues."
25726523
signor
"We found that akt directly phosphorylates the transcription factor gata-1 at serine 310 and that this site-specific phosphorylation is required for the transcriptional activation of the timp-1 promoter."
16107690
reach
"It has also been reported that Akt dependent phosphorylation of GATA-1 at serine 310 is necessary for EPO induced erythrocyte terminal differentiation in a proerythroblast cell line XREF_BIBR and for EPO induced TIMP1 secretion and maturation of fetal liver erythroid cells XREF_BIBR."
23717580
sparser
"AKT serine threonine kinase phosphorylates GATA-1S310 in vitro and in erythroid cells and enhances GATA-1 transcriptional activity."
16204311
reach
"AKT phosphorylates GATA-1 at Ser 310 and enhances its transcriptional activity in primary fetal liver cells (42)."
18469073
phosphoelm
No evidence text available
16107690
sparser
"AKT phosphorylates GATA-1 at Ser-310 and enhances its transcriptional activity in primary fetal liver cells (42) ."
18469073
reach
"Here, we show that erythropoietin activates AKT, which phosphorylates GATA-1 at Ser310, thereby increasing GATA-1 affinity for FOG-1."
26680303
sparser
"It has also been reported that Akt-dependent phosphorylation of GATA-1 at serine 310 is necessary for EPO-induced erythrocyte terminal differentiation in a proerythroblast cell line xref and for EPO-induced TIMP1 secretion and maturation of fetal liver erythroid cells xref ."
23717580
sparser
"Here, we show that erythropoietin activates AKT, which phosphorylates GATA-1 at Ser310, thereby increasing GATA-1 affinity for FOG-1."
26680303
Kinase-active AKT leads to the phosphorylation of GATA1 on serine. 1 / 1
1 |
bel
"The PI3-kinase/AKT signaling pathway is identified as a mediator of Epo-induced phosphorylation of GATA-1. AKT serine threonine kinase phosphorylates GATA-1S310 in vitro and in erythroid cells and enhances GATA-1 transcriptional activity. "
16204311
Kinase-active AKT phosphorylates GATA1 on S310. 1 / 1
1 |
bel
"PhosphoElm data from PMID 15212693"
16107690
AKT phosphorylates GATA1 on S26. 1 / 1
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"GATA1 can be strongly phosphorylated at residue Ser26 of the N-terminal acidic activation domain by MAPK and at Ser310 of the DNA binding domain by Akt in response to growth factors such as Epo."
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