IndraLab

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AKT phosphorylates GATA1. 12 / 12
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"PI3K and AKT stimulates the phosphorylation and activation of GATA1 [XREF_BIBR], and activated GATA-1 upregulates its own gene expression through positive feedback regulation [XREF_BIBR]."
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"Among its pleiotropic effects on erythroid cells, EPO-induced Akt activation promotes differentiation because Akt phosphorylates and activates GATA1 , providing a possible explanation for our observation that inhibition of Akt activity is associated with truncated differentiation."
32520308
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"AKT phosphorylates GATA-1 in erythroid cells xref and K562 cells xref resulting in an increase in its DNA-binding affinity and enhanced transcriptional activity."
26035685
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"It has been reported that the activation of the PI3K/AKT pathway induces the phosphorylation of GATA-1 (Zhao et al., 2006)."
34603025
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"AKT has previously been shown to induce TIMP-1 expression by directly phosphorylating and activating GATA1."
23250987
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"Therefore, these results suggest that gastrodin stimulates the PI3K/AKT pathway and that activation of the PI3K/AKT pathway promotes USP4 expression by enhancing the phosphorylation of GATA1 in HepG2 cells."
34603025
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"AKT phosphorylates GATA-1 in erythroid cells XREF_BIBR and K562 cells XREF_BIBR resulting in an increase in its DNA binding affinity and enhanced transcriptional activity."
26035685
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"Here, we show that erythropoietin activates AKT, which phosphorylates GATA-1 at Ser310, thereby increasing GATA-1 affinity for FOG-1."
26680303
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"Of these, JAK2-STAT5 activates Bcl-xL to prevent apoptosis of erythroid progenitors, whereas Akt promotes differentiation by phosphorylating the essential erythroid transcription factor GATA1 and activating metabolic pathways via phosphorylation of the mTORC1 complex."
32520308
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"Among its pleiotropic effects on erythroid cells, EPO induced Akt activation promotes differentiation because Akt phosphorylates and activates GATA1, providing a possible explanation for our observation that inhibition of Akt activity is associated with truncated differentiation."
32520308
sparser
"Among its pleiotropic effects on erythroid cells, EPO-induced Akt activation promotes differentiation because Akt phosphorylates and activates GATA1 (Zhao et al., 2006), providing a possible explanation for our observation that inhibition of Akt activity is associated with truncated differentiation."
32520308
sparser
"Among its pleiotropic effects on erythroid cells, EPO-induced Akt activation promotes differentiation because Akt phosphorylates and activates GATA1 ( xref ), providing a possible explanation for our observation that inhibition of Akt activity is associated with truncated differentiation."
32520308