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AKT phosphorylates GATA1 on S310. 23 / 27
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"Kadri et al. show that erythropoietin activates AKT, which phosphorylates GATA-1 at Ser310, thereby increasing GATA-1 affinity for FOG-1."
26680303
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"We establish a novel pathway in which Epo-R stimulation activates AKT, which phosphorylates GATA-1 on Ser310; in turn, FOG-1 is then competent to associate with GATA-1pS310, thereby releasing pRb/E2F and, subsequently, free E2F-2, a final effector of cell proliferation."
26680303
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"These experiments confirm that AKT phosphorylates GATA-1 at Ser310 and that this modification is required for FOG-1 binding to GATA-1."
26680303
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"The resumption of normal cell cycle kinetics is induced by erythropoietin, which triggers the phosphorylation of GATA-1 at Ser 310 by AKT, thereby increasing the affinity of GATA-1 for FOG-1 ( Kadri e[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29262331
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"To investigate possible mechanisms of action, we examined the capacity of TG101348 to inhibit JAK2 driven STAT5-phosphorylation and AKT-mediated GATA-1 S310 phosphorylation as well as GATA-1 and PU.1 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18394555
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"Epo-R stimulation activates AKT, which phosphorylates GATA-1 at Ser310, thereby increasing the affinity of GATA-1 for FOG-1."
26680303
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"AKT serine threonine kinase phosphorylates GATA-1S310 in vitro and in erythroid cells and enhances GATA-1 transcriptional activity."
16204311
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"Thus, the transcriptional activities of GATA-1 and E2F-2 factors are inversely correlated and depend on both the activity of AKT kinase, which phosphorylates GATA-1 at Ser310, and that of the unknown phosphatase that dephosphorylates this residue."
26680303
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"It has also been reported that Akt-dependent phosphorylation of GATA-1 at serine 310 is necessary for EPO-induced erythrocyte terminal differentiation in a proerythroblast cell line xref and for EPO-induced TIMP1 secretion and maturation of fetal liver erythroid cells xref ."
23717580
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"Epo-R stimulation activates AKT, which phosphorylates GATA-1 at Ser310, thereby increasing the affinity of GATA-1 for FOG-1."
26680303
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"AKT phosphorylates GATA-1 at Ser 310 and enhances its transcriptional activity in primary fetal liver cells (42)."
18469073
sparser
"Kadri et al. show that erythropoietin activates AKT, which phosphorylates GATA-1 at Ser310, thereby increasing GATA-1 affinity for FOG-1."
26680303
sparser
"Here, we show that erythropoietin activates AKT, which phosphorylates GATA-1 at Ser310, thereby increasing GATA-1 affinity for FOG-1."
26680303
sparser
"The hematopoietic factor GATA-1 is phosphorylated by AKT at Ser310."
29262331
reach
"The resumption of normal cell cycle kinetics is induced by erythropoietin, which triggers the phosphorylation of GATA-1 at Ser 310 by AKT, thereby increasing the affinity of GATA-1 for FOG-1 ( Kadri e[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29262331
sparser
"We establish a novel pathway in which Epo-R stimulation activates AKT, which phosphorylates GATA-1 on Ser310; in turn, FOG-1 is then competent to associate with GATA-1pS310, thereby releasing pRb/E2F and, subsequently, free E2F-2, a final effector of cell proliferation."
26680303
sparser
"Phosphorylation of GATA-1 at Ser310 by AKT enhances the association of GATA-1 with FOG-1."
26680303
sparser
"AKT phosphorylates GATA-1 at Ser-310 and enhances its transcriptional activity in primary fetal liver cells (42) ."
18469073
sparser
"These experiments confirm that AKT phosphorylates GATA-1 at Ser310 and that this modification is required for FOG-1 binding to GATA-1."
26680303
sparser
"It has been reported that Akt directly phosphorylated GATA1 at serine 310 [ xref ], and PAK5 was in higher expression in breast cancer tissues than matched adjacent noncancerous tissues."
25726523
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"The hematopoietic factor GATA-1 is phosphorylated by AKT at Ser310."
29262331
reach
"It has also been reported that Akt dependent phosphorylation of GATA-1 at serine 310 is necessary for EPO induced erythrocyte terminal differentiation in a proerythroblast cell line XREF_BIBR and for EPO induced TIMP1 secretion and maturation of fetal liver erythroid cells XREF_BIBR."
23717580
sparser
"Thus, the transcriptional activities of GATA-1 and E2F-2 factors are inversely correlated and depend on both the activity of AKT kinase, which phosphorylates GATA-1 at Ser310, and that of the unknown phosphatase that dephosphorylates this residue."
26680303