IndraLab

Statements

RET activates AKT. 10 / 60
2 | 2 51 3
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"Following treatment with the drug combination, Akt phosphorylation was completely abrogated while, after dasatinib alone, Akt activation was not affected, confirming that Akt activation is driven by RET and not by the FAK and Src complex [XREF_BIBR, XREF_BIBR]."
20955590
reach
"Protein RAS and fusion protein RET and PTC may activate the PI3K and AKT (phosphatidylinositol 3-kinase/Akt) signaling pathway through the loss of function of PTEN [XREF_BIBR]."
20369062
sparser
"Also, interestingly, the ligand-induced activation of AKT by wild-type RET is dependent on the localization in lipid rafts, and this regulatory mechanism is bypassed by RET-MEN2A [30] ."
16979782
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"RET9 and RET51 activate PI3K and AKT and ERK signalling with different dynamics and have distinct abilities to recruit Src or Frs2, suggesting differential activation of downstream targetsby the two main RET isoforms."
27841748
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"In one scenario, RET phosphorylation induces SRC family kinases (SFKs) and PI3K and AKT activation and ultimately the upregulation of Mycn."
28286576
reach
"Interaction of RET protein with its ligands (glial cell derived neurotrophic factor (GDNF), neurturin (NRTN), and artemin (ARTN)) and its co-receptors (GDNF receptor alpha proteins (GFRα1-4)) activates the Phosphoinositide-3-kinase-protein kinase B (PI3K-PKB/AKT), RAS mitogen-activated protein kinase (RAS/MAPK) and phospholipase Cγ (PLCγ) signaling pathways, which control the survival, migration, proliferation, differentiation, and maturation of the vagal and sacral neural crest cells into enteric neurons."
35434281
reach
"Additionally, RET- FAK crosstalk may play a key role in facilitating PTC1 and RET and GDNF- RET induced activation of Akt and MAPK signaling in TPC1 and MCF7 cells."
25409876
signor
"The PKB Y315 residue, which is known to be phosphorylated by Src tyrosine kinase, was also a major site of phosphorylation by RET/PTC. RET/PTC-mediated tyrosine phosphorylation results in the activation of PKB kinase activity"
15994200
reach
"Previous studies have shown that a subset of ERalpha positive breast cancers express high levels of mRNA transcripts encoding RET and that RET signaling in ERalpha positive breast cancer cell lines can result in the activation of MAPK and AKT, which are important regulators of ERalpha phosphorylation [XREF_BIBR, XREF_BIBR]."
23151593
sparser
"We believe that the failure of Akt activation by Ret is a direct consequence of its inability to bind Shc, which has been shown to trigger Akt phosphorylation when bound to Ret ."
18353552
Mutated RET activates AKT. 3 / 3
| 3
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"The greater sensitivity of MZ-CRC1 to AZD1480 compared with TT (harboring the less aggressive C634W mutation), might be explained by different capacities of MEN2A- and MEN2B- RET mutants to activate downstream pathways, namely the PI3K and AKT pathway XREF_BIBR."
23056499
reach
"Mutant RET with representative MEN2A mutation at Cys 634 (RET-MEN2A) has been shown to activate PI3 kinase and Akt pathway."
23158190
reach
"RET mutants significantly enhance the activation of RET and its downstream MAPK and AKT signaling pathway in ovarian cancer cells."
32293499
RET bound to ptc activates AKT. 1 / 1
| 1
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"The ligand independent dimerization of RET and PTC protein leads to chronic stimulation of MAPK and PI3K-AKT signaling and increased cell proliferation and transformation in thyroid cells [XREF_BIBR, XREF_BIBR]."
22562579
Kinase-active RET activates AKT. 1 / 1
1 |
bel
"Activation of RET, either by ligand or through specific mutations, results in phosphorylation of multiple tyrosine residues that, in turn, interact with specific adaptor molecules to trigger downstream signaling. Four of the tyrosines phosphorylated on RET activation, tyrosines 905, 1015, 1062, and 1096, have been well characterized, and are known to interact with a number of adaptor molecules to stimulate signaling through phosphatidylinositol kinase (PI3K)/AKT, PLC-gamma, RAS/extracellular signal-regulated kinase (ERK), p38MAPK, JNK and ERK5."
15231654