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RET activates AKT. 82 / 86
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"Ret activates the Ras and Erk MAP kinase, PLCgamma-Ca + and PI3K-Akt signaling pathways, all of which are important for normal kidney development."
20493806
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"RET and PTC, Ras, and receptor tyrosine kinase could dually activate the PI3K and Akt and MAPK pathways."
20578891
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"We observed, as we have previously described, that the presence of GAS1 reduces RET phosphorylation and inhibits the activation of AKT."
22311470
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"Additionally, RET can activate AKT from the cell surface, but the RAS/ERK pathway is activated only after RET has become internalized [11] ."
37595672
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"RET acts through PI3K to stimulate protein kinase AKT [5] and has also been shown to activate the c-JUN pathway through a cdc42/RAC GTPase and p38 mitogen-activated protein kinase (MAPK) pathway [2,6][MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16843637
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"IRS-1 coimmunoprecipitates with Ret and co-expression of IRS-1 results in the potentiation of Ret mediated activation of Akt (PKB), a bona fide effector of PI3-K."
11313948
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"Following treatment with the drug combination, Akt phosphorylation was completely abrogated while, after dasatinib alone, Akt activation was not affected, confirming that Akt activation is driven by RET and not by the FAK and Src complex [XREF_BIBR, XREF_BIBR]."
20955590
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"Further studies will be necessary to demonstrate if the effects of neurturin on process outgrowth in PPSCs-derived cells may be mediated by Ret-independent pathways activating Akt, MAPK, PLCγ or Src-f[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15896320
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"We believe that the failure of Akt activation by Ret is a direct consequence of its inability to bind Shc, which has been shown to trigger Akt phosphorylation when bound to Ret ."
18353552
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"RET proto-oncogene The RET proto-oncogene can activate RAS and extracellular signalregulated kinase (ERK), PI3K and Akt, MAP kinase, and other signaling pathways."
29629846
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"Abnormal fusion of RET can activate RAS/MAPK, ERK, PI3K/AKT, JAK/STAT, and other downstream signaling pathways."
37924363
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"RET and PTC stimulates both the PI3K and AKT and the ERK pathways by recruiting several adaptors to phosphorylated Y1062."
19223551
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"Ligand activation of the RET kinase activates a cascade of signaling pathways, e.g., JAK, MAPK, c-Jun, NH2-terminal kinase, Ras/Raf/MAPK, NF-kappaB, and the PI3K and AKT pathways 31."
19903778
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"Western blot analyses showed that RET inhibition abolishes AKT and ERK1/2 activation."
33269540
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"The deletion of asparagine 1059 (delN1059) and the substitution of leucine 1061 (L1061P), two Ret mutations identified in families affected by congenital megacolon (Hirschsprung 's disease), impair the binding of IRS-1 to Ret as well as Ret mediated Akt (PKB) stimulation."
11313948
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"RET signaling activates ERK or AKT signaling depending on context, but phosphorylation of p70S6 kinase is markedly increased in all cases."
28490466
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"TPC1 cells are a thyroid cancer cell line that contain a RET and PTC rearrangement that can activate the PI3K-Akt pathway; therefore, these complex observations may stem from the different gene expression profiles in the two cancer cell lines."
29675113
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"Indeed, in a neuroectodermic cell line, AKT activation by Ret was shown to be essential to counteract the apoptotic signal on mitochondria, and Ret-mediated activation of ERK was found to contribute t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16756963
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"RET signaling can activate both the PI3K and AKT and MAPK and ERK signaling pathways through phosphorylation of tyrosine 1062 in RET."
28490466
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"25 While RET activation principally induces the RAS-RAF-MEK-ERK mitogen activated protein kinase (MAPK) pathway, RET can also activate phosphatidylinositol-3-kinase and Akt (PI3K and Akt), janus activated kinase and signal transducers and activators of transcription (JAK and STAT), and jun-N terminal kinase (JNK), among other pathways (XREF_FIG)."
24942936
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"Dominant activating mutations of RET (Rearranged during Transfection) proto-oncogene have been identified in MTC, and constitutively active RET kinases activate the PI3K and Akt pathway [XREF_BIBR]."
23900743
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"RET9 and RET51 activate PI3K and AKT and ERK signalling with different dynamics and have distinct abilities to recruit Src or Frs2, suggesting differential activation of downstream targetsby the two main RET isoforms."
27841748
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"The association of ShcD with RET is not an extraordinary finding for Shc family proteins since ShcC has been identified as a physiological substrate of the activated RET oncoprotein, which activates the PI3K and AKT signalling pathway and promotes cancer cell survival XREF_BIBR."
29556564
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"Interaction of RET protein with its ligands (glial cell derived neurotrophic factor (GDNF), neurturin (NRTN), and artemin (ARTN)) and its co-receptors (GDNF receptor alpha proteins (GFRα1-4)) activates the Phosphoinositide-3-kinase-protein kinase B (PI3K-PKB/AKT), RAS mitogen-activated protein kinase (RAS/MAPK) and phospholipase Cγ (PLCγ) signaling pathways, which control the survival, migration, proliferation, differentiation, and maturation of the vagal and sacral neural crest cells into enteric neurons."
35434281
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"RET overexpression was shown to promote AKT activation, which is consistent with previous reports, however coexpression with ShcD inhibited this activation in the presence of GDNF."
29556564
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"The small molecule inhibitor SPP86 is a selective inhibitor of RET tyrosine kinase, which induces PI3K and Akt and MAPK signaling that affects cell migration and differentiation."
33148376
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"Ret induces the serine/threonine kinase AKT and extracellular signal regulated kinase (ERK) signaling which mediate pro survival and neurotrophic activities."
28442998
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"6 , 7 Together with a reported in vitro study demonstrating that RET‐GOLGA5 fusion gene accelerates the cell proliferation by activating AKT, ERK, S6, and PLCy‐1, 8 it remains possible that RET‐GOLGA5 fusion gene in the main enlarging nodule of the present case was acquired by internal irradiation therapy with radioiodine after thyroidectomy, enhancing the growth rate as well as modifying epigenetically the morphology and immunophenotype of one of the metastatic nodules of PTC."
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"Here, we have shown that RET activates protein kinase B (AKT) to inhibit glycogen synthesis kinase-3β (GSK3β), resulting in activation of HH signaling and subsequent induction of NB cell proliferation[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27316313
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"Finally, activation of the RET proto-oncogene can activate the PI3K and Akt pathway, and activating mutations of the RET protein are associated with both sporadic and hereditary MTC [XREF_BIBR]."
23900743
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"RET activated PI3K and Akt and MAPK pathways play fundamental roles in the tumorigenesis and progression of thyroid cancer [14]."
24220341
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"Ret is a potent activator of both PI3K and Akt and Ras and ERK, and the loss of cell bodies, axons, and reduced cell size in DAT-Ret mice suggest possible defects in PI3K and Akt and/or Ras and ERK signaling."
20386724
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"RET receptor tyrosine kinase autophosphorylation can activate various signaling pathways including RAS/ERK, PI3K/AKT and p38MAPK ( Worby et al., 1996; Xing et al., 1998; Chiariello et al., 1998; Trupp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21619889
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"Interestingly, SPP86 and PF573228 inhibited RET and PTC1 and GDNF- RET induced activation of Akt and MAPK signaling to a similar degree."
25409876
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"RET stimulates MAPK and Akt and PKB signalling pathways, through Ras-Raf-Merk-Erk, Ras-PI3-K/Akt/PKB in vivo and vitro (Melillo et al, 2005; Mitsutake et al, 2006; Santoro et al, 2006)."
18985036
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"Additionally, RET- FAK crosstalk may play a key role in facilitating PTC1 and RET and GDNF- RET induced activation of Akt and MAPK signaling in TPC1 and MCF7 cells."
25409876
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"RET stimulates MAPK and Akt and PKB signalling pathways, through Ras-Raf-Merk-Erk, Ras-PI3-K/Akt/PKB in vivo and vitro (Melillo et al, 2005; Mitsutake et al, 2006; Santoro et al, 2006)."
18985036
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"Mammalian Ret on the other hand, has been extensively characterized and is known to activate a number of downstream signaling pathways including Ras and ERK, phosphoinositol-3 kinase (PI3K)/Akt, phospholipase C-gamma (PLCgamma), Janus kinase (JAK)/STAT, and ERK5, several of which have pro survival effects, most notably the PI3K and Akt pathway."
24473149
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"SPP86 may thus inhibit RET- mediated Akt activation in this cell line."
25409876
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"The activation of PKB by RET and PTC blocked the activity of the forkhead transcription factor, FKHRL1, but a Y315F mutant of PKB failed to inhibit FKHRL1 activity."
15994200
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"Furthermore, it is likely that cochlear neurons behave differently from nodose neurons, in which Ret but not NCAM activates PI3K and Akt signaling upon GDNF and GFRalpha1 stimulation."
23262364
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"Here, we have shown that RET activates protein kinase B (AKT) to inhibit glycogen synthesis kinase-3β (GSK3β), resulting in activation of HH signaling and subsequent induction of NB cell proliferation[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27316313
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"Indeed, in a neuroectodermic cell line, AKT activation by Ret was shown to be essential to counteract the apoptotic signal on mitochondria, and Ret-mediated activation of ERK was found to contribute t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16756963
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"Protein RAS and fusion protein RET and PTC may activate the PI3K and AKT (phosphatidylinositol 3-kinase/Akt) signaling pathway through the loss of function of PTEN [XREF_BIBR]."
20369062
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"PF573228 also inhibited RET- dependent activation of Akt and ERK1/2 in MCF7 cells to a similar degree as SPP86."
25409876
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"Activating RET alterations have been shown to enhance the activity of the PI3K/AKT and MAPK pathways, thereby promoting the proliferation and development of various types of tumor cells (Brzezianska and Pastuszak-Lewandoska, 2011; Regua et al., 2022)."
38957390
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"In MEN2 and NF1 syndromic cases, the RET and NF1inactivating mutations causes the activation of Ras/MAPK and PI3K/AKT pathways (34)."
30386298
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"In this region, GFRAL signals through Ret proto-oncogene (RET) to induce activation of AKT, ERK1/2, and PLCγ ( Figure 1 ) ( Tsai et al., 2018 )."
32877689
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"Wild-type and truncated forms of RET and PTC activate the PI3K and AKT pathway leading to tumorigenesis [XREF_BIBR, XREF_BIBR]."
21765995
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"RET fusion could activate the downstream PI3K/AKT, RAS/MAPK, and JAK/STAT pathways, which further promoted tumor proliferation, differentiation, migration."
35707347
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"Certainly the mechanism by which RET signaling results in mTOR activation independently of AKT is worthy of further investigation, because targeting RET downstream signaling pathways might be a therap[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24705026
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"Thus, RET possibly activates AKT and in turn inhibits GSK3β to induce HH signaling in growth of SH-SY5Y cell xenografts.To further confirm the critical role of GLIs in RET-activated HH signaling in pr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27316313
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"RET phosphorylation activates the AKT, ERK1/2, and PKC signaling pathways."
38892145
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"RET activation triggers both MAPK and PI3K-AKT intracellular pathways (Santoro et al., 1994; van Weering and Bos, 1997)."
29859890
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"Ret WT activated the Akt signaling pathway maximally at 30 and 60 min of stimulation, while negative control Ret Y1062F and Ret Dok+ displayed very low levels of Akt activation at all time points stud[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18353552
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"We believe that the failure of Akt activation by Ret Dok+ is a direct consequence of its inability to bind Shc, which has been shown to trigger Akt phosphorylation when bound to Ret [12]."
18353552
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"Additionally, RET can activate AKT from the cell surface, but the RAS/ERK pathway is activated only after RET has become internalized [11] ."
37595672
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"RET signaling leads to activation of the RAS/mitogen-activated protein kinase and the phosphatidylinositol 3′kinase/Akt pathways, having a key role in cell growth, differentiation, and survival."
21459081
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"This Ret-dependent activation of Akt is an important characteristic of enteric neurons."
18471518
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"Upon activation, RET is transphosphorylated at cytoplasmic tyrosine residues and triggers complex intracellular signaling cascades, Akt, MAPK, and c-Src signaling pathways, promoting the survival and regeneration of neurons (modified from Airaksinen and Saarma, 2002)."
34149364
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"Rearrangement of the RET gene can directly or indirectly activate the MAPK and PI3K/AKT pathways."
37904863
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"GDNF promotes cancer progression by binding to GDNF family receptors α1-3 and RET proto-oncogene (RET), which initiate the downstream activation of several signaling pathways, including RAS/ERK, MAPK, JNK, and PI3-K/Akt [105,106]."
37566075
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"Proliferation of thyroid cancer cells OCUT1, K1, FTC133, C643, Hth7, and TPC1, which harbored PIK3CA, PTEN, Ras, or RET and PTC mutations that could activate the PI3K and Akt pathway, was potently inhibited by MK2206 with IC (50) values mostly below or around 0.5 mum."
21289267
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"In one of the mechanisms, RET phosphorylation stimulates the activation of PI3K/AKT and SRC-family kinases (SFKs), allowing spermatogonia proliferation [71,72]."
36768269
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"Upon activation , RET is transphosphorylated at cytoplasmic tyrosine residues and triggers complex intracellular signaling cascades , Akt , MAPK , and c-Src signaling pathways , promoting the survival and regeneration of neurons ( modified from Airaksinen and Saarma , 2002 ) ."
34149364
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"The PI3K and Akt signaling can also be activated by RET and PTC or Ras."
19706758
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"The oncogenic RET has been shown to activate PI3K/AKT and RAS/RAF/MAPK dependent pathways, and its eventual activation of mTOR may constitute a common mechanism of tumor development."
36341186
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"This Ret dependent activation of Akt is an important characteristic of enteric neurons."
18471518
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"Santoro et al. reported that RET/PTC chromosomal rearrangement activated the PI3K/AKT pathway in papillary thyroid carcinoma [19]."
35757470
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"Activation of the Ret kinase inhibits apoptosis and promotes survival through Ret induced AKT signaling, making apoptosis and survival of neurons dependent on the presence of GFRalpha receptors [XREF_BIBR]."
29367572
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"Previous studies have shown that a subset of ERalpha positive breast cancers express high levels of mRNA transcripts encoding RET and that RET signaling in ERalpha positive breast cancer cell lines can result in the activation of MAPK and AKT, which are important regulators of ERalpha phosphorylation [XREF_BIBR, XREF_BIBR]."
23151593
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"Stimulation of Ret51 expressing cells also fail to induce sustained activation of Erk-MAPK and can not activate PKB-Akt (XREF_FIG)."
15569713
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"In one scenario, RET phosphorylation induces SRC family kinases (SFKs) and PI3K and AKT activation and ultimately the upregulation of Mycn."
28286576
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"Western blot analyses showed that RET inhibition abolishes AKT and ERK1 / 2 activation ( Fig. 5G ) ."
33269540
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"Then RET can be abnormally expressed in normally transcriptionally silenced cells, thereby activating the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/retrovirus from AKR mice (AKT) signaling pathway being activated, which drives tumorigenesis and development of tumors (6)."
35571397
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"Also, interestingly, the ligand-induced activation of AKT by wild-type RET is dependent on the localization in lipid rafts, and this regulatory mechanism is bypassed by RET-MEN2A [30] ."
16979782
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"Certainly the mechanism by which RET signaling results in mTOR activation independently of AKT is worthy of further investigation, because targeting RET downstream pathways might be an important thera[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21251878
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"(A) Inhibition of Akt activation by the Ret and Met tyrosine kinase inhibitor RPI-1."
19107227
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"In addition, the proto-oncogene RET and PTC induces nuclear accumulation of beta-catenin in PTC by activating the PI3K and AKT and MAPK signaling pathways, but the precise mechanism underlying beta-catenin dysregulation in differentiated thyroid carcinoma remains unknown [XREF_BIBR, XREF_BIBR]."
29383135
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"In SH-SY5Y neuroblastoma cells this regulation seems to be mediated through the PI3K/AKT pathway, which in turn can be activated by RET."
38666930
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"The activation of RET in thyroid cancer can activate pathways like MAPK/ERK and PI3K/AKT which can promote cell growth and survival [ 34 ]."
37734434
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"Previous studies have revealed that RET activates the Raf and MEK and PI3K and Akt downstream signaling pathways, which in turn phosphorylate and activate ERK1/2 and mammalian target of rapamycin (mTOR) proteins, respectively."
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