IndraLab

Statements

Mutated RET activates AKT. 3 / 3
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reach
"The greater sensitivity of MZ-CRC1 to AZD1480 compared with TT (harboring the less aggressive C634W mutation), might be explained by different capacities of MEN2A- and MEN2B- RET mutants to activate downstream pathways, namely the PI3K and AKT pathway XREF_BIBR."
23056499
reach
"Mutant RET with representative MEN2A mutation at Cys 634 (RET-MEN2A) has been shown to activate PI3 kinase and Akt pathway."
23158190
reach
"RET mutants significantly enhance the activation of RET and its downstream MAPK and AKT signaling pathway in ovarian cancer cells."
32293499