IndraLab

Statements

PDPK1 phosphorylates AKT1 on T308. 10 / 68
12 1 6 6 2 | 17 16 5
hprd
No evidence text available
10226025
rlimsp
"Expressed PDK1 and DSTPK61 phosphorylated Thr308 of PKB alpha only in the presence of Ptdlns(3,4,5)P3 or Ptdlns(3,4)P2."
9368760
biopax:pid
No evidence text available
12242303
biopax:pid
No evidence text available
15550174
biopax:pid
No evidence text available
7637810
hprd
No evidence text available
10226025
reach
"Thr 308 of PKBalpha and Thr 252 of p70 S6 kinase are phosphorylated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) in vitro."
10601311
sparser
"Inactivation of GSK-3β Y216 was followed by the phosphorylation of Akt1 T308 by PDK1."
20041157
reach
"Phosphoinositide-dependent-protein kinase 1 (PDK1) phosphorylates AKT1 at threonine 308, and the second phosphorylation takes place at serine 473 by mTOR complex 2."
33815613
sparser
"In the cell-free assay Li2CO3 significantly inhibited phosphoinositide 3-kinase (PI3K)-mediated phosphorylation of Akt1 at Ser473, but Li2CO3 did not affect PI3K-mediated PI(3,4,5)P3 production and 3-phosphoinositide-dependent protein kinase 1 (PDK1)-mediated phosphorylation of Akt1 at Thr308."
24950409
PDPK1 phosphorylates AKT1. 10 / 61
| 29 23 5
reach
"Mechanistically, PDK1 phosphorylates AKT1 in a critical activation site at T308 (T309 in AKT2) in the activation loop of the kinase domain, while mTORC2 phosphorylates AKT on S473 (S474 in AKT2) in the C-terminal hydrophobic motif [XREF_BIBR, XREF_BIBR]."
28237819
sparser
"Akt1 is phosphorylated by PDK1, and thereby activated upon translocation to the membrane [22,23] ."
12928036
reach
"The binding of circAmotl1 to 3-phosphoinositide-dependent protein kinase 1 (PDK1) and protein kinase B (AKT1) facilitates the PDK1 dependent phosphorylation of AKT1 [51]."
32751850
reach
"PIP3 generates membrane docking sites for both Phosphotidylinositol Dependent Kinase 1 (PDK1) and for the serine/threonine protein kinase AKT-1 through their pleckstrin homology domains, where PDK1 phosphorylates and activates AKT-1."
25009292
reach
"Akt1, Akt2 and Akt3 were phosphorylated and activated by PDK1 at similar rates and to similar extents."
11410335
sparser
"PDK-dependent Akt1 phosphorylation is reversed by protein phosphatase 2A (PP2A) which dephosphorylates pT308 and, to a lesser extent, pS473."
25474128
sparser
"The binding of circAmotl1 to 3-phosphoinositide-dependent protein kinase 1 (PDK1) and protein kinase B (AKT1) facilitates the PDK1-dependent phosphorylation of AKT1 [51]."
32751850
reach
"PDK1 then phosphorylates AKT1 at one of its two key sites, T308."
30875364
sparser
"PDK1 phosphorylates Akt1 at Thr xref , suggesting that another protein kinase, namely PDK2, is responsible for Ser 473 phosphorylation."
29200866
sparser
"For example, circAmotl1 physically binds to 3-phosphoinositide-dependent protein kinase 1 (PDK1) and protein kinase B (AKT1) to promote PDK1-dependent AKT1 phosphorylation."
32758239
PDPK1 phosphorylates AKT1 on S473. 10 / 18
7 1 1 3 1 | 4 1
reach
"In general, receptor- or non-receptor tyrosine kinases, PI3K, the 3-phosphoinositide-dependent protein kinase 1 (PDK1) and mTOR complex 2 (mTORC2) can activate Akt by promoting the phosphorylation of Akt1, Akt2 and Akt3 at residues T308/S473, T309/S474 and T305/S472, respectively [83]."
34419139
biopax:pid
No evidence text available
9094314
reach
"PDK1 directly phosphorylates Akt1 at T308, while mTORC2 not only directly phosphorylates Akt1 at S473, but also phosphorylates and activates insulin receptor (InsR)/insulin-like growth factor receptor (IGF-IR) through the tyrosine kinase activity of mTOR, thereby indirectly promoting Akt activation [83, 85]."
34419139
phosphoelm
No evidence text available
10226025
biopax:netpath
No evidence text available
10438924
biopax:pid
No evidence text available
9094314
biopax:pid
No evidence text available
12538620
biopax:pid
No evidence text available
hprd
No evidence text available
10226025
hprd
No evidence text available
10226025
PDPK1 phosphorylated on S241 phosphorylates AKT1 on T308. 9 / 9
9 |
biopax:pid
No evidence text available
12750173
biopax:pid
No evidence text available
11136732
biopax:pid
No evidence text available
18596232
biopax:pid
No evidence text available
11809791
biopax:pid
No evidence text available
20153221
biopax:pid
No evidence text available
11241670
biopax:pid
No evidence text available
16033886
biopax:pid
No evidence text available
14666721
biopax:pid
No evidence text available
10570282
PDPK1 phosphorylates AKT1 on Y474. 6 / 6
6 |
biopax:pid
No evidence text available
9094314
biopax:pid
No evidence text available
16787925
biopax:pid
No evidence text available
biopax:pid
No evidence text available
12538620
biopax:pid
No evidence text available
9094314
biopax:pid
No evidence text available
9094314
PDPK1 phosphorylated on S241 phosphorylates AKT1 on S473. 3 / 3
3 |
biopax:pid
No evidence text available
11809791
biopax:pid
No evidence text available
11241670
biopax:pid
No evidence text available
14666721
PDPK1 phosphorylates AKT1 on threonine. 2 / 2
| 1 1
reach
"PDK1 phosphorylates Akt1 at Thr XREF_BIBR, suggesting that another protein kinase, namely PDK2, is responsible for Ser 473 phosphorylation."
29200866
rlimsp
"The PI3K-dependent Akt serine/threonine phosphorylation by PDK1 and mTORC2 has long been thought to be the primary mechanism accounting for Akt activation."
25309720
Modified PDPK1 leads to the phosphorylation of AKT1. 1 / 1
| 1
reach
"Di-Poi et al. demonstrated this mechanism by elucidating that the proliferative effect of PPAR beta and delta was mediated through the direct repression of gene expression of phosphatase and tensin homolog deleted on chromosome ten (PTEN) and increase expression of 3-phosphoinositide-dependent-protein kinase 1 (PDK1), which then activated the phosphorylation of protein kinase B (Akt), leading to cell proliferation of keratinocytes [XREF_BIBR]."
33424958
Modified PDPK1 leads to the phosphorylation of AKT1 on T308. 1 / 1
| 1
reach
"Overexpression of PDK1 in 293 cells activated PKB alpha and potentiated the IGF1 induced phosphorylation of PKB alpha at Thr308."
9368760
PDPK1 phosphorylates AKT1-S473D. 1 / 1
| 1
reach
"GST-Akt S473D (125 nM) and GST-Akt S473D ΔPH (125 nM) were phosphorylated by 1 nM GST PDK1, whereas GST-SGK S422D (1 μM) was phosphorylated by 0.05 nM GST PDK1."
37311034
PDPK1 leads to the phosphorylation of AKT1 on T305. 1 / 1
| 1
reach
"In general, receptor- or non-receptor tyrosine kinases, PI3K, the 3-phosphoinositide-dependent protein kinase 1 (PDK1) and mTOR complex 2 (mTORC2) can activate Akt by promoting the phosphorylation of Akt1, Akt2 and Akt3 at residues T308/S473, T309/S474 and T305/S472, respectively [83]."
34419139
PDPK1 phosphorylated on S241 phosphorylates AKT1 on Y474. 1 / 1
1 |
biopax:pid
No evidence text available
11809791