IndraLab

Statements

PDPK1 phosphorylates AKT1 on S473. 18 / 18
7 1 1 3 1 | 4 1
reach
"In general, receptor- or non-receptor tyrosine kinases, PI3K, the 3-phosphoinositide-dependent protein kinase 1 (PDK1) and mTOR complex 2 (mTORC2) can activate Akt by promoting the phosphorylation of Akt1, Akt2 and Akt3 at residues T308/S473, T309/S474 and T305/S472, respectively [83]."
34419139
biopax:pid
No evidence text available
9094314
reach
"PDK1 directly phosphorylates Akt1 at T308, while mTORC2 not only directly phosphorylates Akt1 at S473, but also phosphorylates and activates insulin receptor (InsR)/insulin-like growth factor receptor (IGF-IR) through the tyrosine kinase activity of mTOR, thereby indirectly promoting Akt activation [83, 85]."
34419139
phosphoelm
No evidence text available
10226025
biopax:netpath
No evidence text available
10438924
biopax:pid
No evidence text available
9094314
biopax:pid
No evidence text available
12538620
biopax:pid
No evidence text available
hprd
No evidence text available
10226025
hprd
No evidence text available
10226025
reach
"AC093818.1 could increase the expression level of PDK1, which can activate the AKT/mTOR pathway by phosphorylating AKT1 at S473."
31988283
hprd
No evidence text available
10226025
reach
"Akt1 is phosphorylated by PDK1 at T308, and additionally at S473 by the Pl3K related kinases, mammalian target of rapamycin complex 2 (mTORC2) or DNA-PK to achieve its full kinase activity, depending on the stimulus and the cellular context."
22272775
biopax:phosphositeplus
No evidence text available
sparser
"It has been shown that PI3,4P2 and PI3,4,5P3, interacting with the PH domain of AKT-1/PKB, promote its translocation to the plasma membrane inducing conformational changes and, in parallel, activate P[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11369519
biopax:pid
No evidence text available
9094314
signor
"We have partially purified a kinase from brain extract that phosphorylates Ser473 of PKBalpha in a PtdIns(3,4,5)P3-dependent manner and that is immunoprecipitated with PDK1 antibodies."
10226025
biopax:pid
No evidence text available
16787925