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IndraLab

Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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SMAD4 activates SMAD4. 6 / 17
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"The sumoylation of Smad4 alters its subnuclear localization, enhances its stability, and increases Smad4 mediated transcriptional activation."
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"Furthermore, the over-expression of miR-224 in CRC cell lines decreased SMAD4 expression at the translational level and decreased SMAD4 driven luciferase reporter activity."
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"We also assessed whether a blockade of Smad4 SUMOylation could prevent Smad4 from binding to the TPM2 promoter in the brain."
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"In contrast to the inhibitory effects of K519 mono-ubiquitylation by ectodermin, Smad4 mono-ubiquitylation at K507 enhanced the capacity of Smad4 to form complexes with activated R-Smads."
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"Smad4 protein expression was down-regulated in 68.4% (26/38) of the cases but up-regulated Smad 4 expression was seen in only one case."
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"However, sumoylation of Smad4 can also suppress TGF-beta and BMP signaling by repressing the transcriptional activity of Smad4."
SMAD4 bound to SP1 activates SMAD4. 1 / 1
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bel
"Smads 3 and 4 have specifically been shown to take part in TGF-beta-mediated CTCF/Smads complex binding of the APP gene promoter that up-regulates APP expression In addition, TGF-beta has been shown to stimulate Smads interaction with the stimulating protein 1 (SP1) transcription factor"
SMAD4 bound to it activates SMAD4. 1 / 1
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"Alternatively, TSC-22 might act as transcriptional regu-lator as it binds to Smad4 via the TSC-box and modulates the transcriptional activity of Smad4 [XREF_BIBR]."
SMAD4 bound to SMAD9 activates SMAD4. 1 / 1
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bel
"Phosphorylation of the C-terminal serine residues in R-Smads by type I receptor kinases is a crucial step in TGF-b family signalling (Abdollah et al., 1997; Macias-Silva et al., 1996; Souchelnytskyi et al., 1997). The two most C-terminal serine residues become phosphorylated and, together with a third, non-phosphorylated serine residue, form an evolutionarily conserved SSXS motif in all R-Smads.... TGF-b and activin receptors phosphorylate Smad2 and Smad3, and BMP receptors phosphorylate Smad1, Smad5 and Smad8 (Chen et al., 1998) (Fig. 1). The consequence of R-Smad phosphorylation is the formation of oligomeric complexes with the Co-Smad, Smad4."
SMAD4 bound to SMAD5 activates SMAD4. 1 / 1
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bel
"Phosphorylation of the C-terminal serine residues in R-Smads by type I receptor kinases is a crucial step in TGF-b family signalling (Abdollah et al., 1997; Macias-Silva et al., 1996; Souchelnytskyi et al., 1997). The two most C-terminal serine residues become phosphorylated and, together with a third, non-phosphorylated serine residue, form an evolutionarily conserved SSXS motif in all R-Smads.... TGF-b and activin receptors phosphorylate Smad2 and Smad3, and BMP receptors phosphorylate Smad1, Smad5 and Smad8 (Chen et al., 1998) (Fig. 1). The consequence of R-Smad phosphorylation is the formation of oligomeric complexes with the Co-Smad, Smad4."