IndraLab

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SMAD4 activates SMAD4. 13 / 22
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"Loss of SMAD4 was associated with both decreased median disease-free survival (28months; 95% confidence interval, 16-40) months compared with 223months (95% confidence interval, 3-443months) for SMAD4 positive patients (P =.03) and decreased median disease specific survival (SMAD4 : 137 [95% confidence interval, 81-194] months versus SMAD4 positive : 204 [95% confidence interval, 143-264] months; P =.04)."

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"The sumoylation of Smad4 alters its subnuclear localization, enhances its stability, and increases Smad4 mediated transcriptional activation."

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"We also assessed whether a blockade of Smad4 SUMOylation could prevent Smad4 from binding to the TPM2 promoter in the brain."

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"However, sumoylation of Smad4 can also suppress TGF-beta and BMP signaling by repressing the transcriptional activity of Smad4."

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"In line with these results, Park etal 1 now found that Wip1 antagonized FGF induced Erk kinase Smad4 Thr277 phosphorylation and prevented Smad4 degradation."

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"Furthermore, the over-expression of miR-224 in CRC cell lines decreased SMAD4 expression at the translational level and decreased SMAD4 driven luciferase reporter activity."

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"In contrast to the inhibitory effects of K519 mono-ubiquitylation by ectodermin, Smad4 mono-ubiquitylation at K507 enhanced the capacity of Smad4 to form complexes with activated R-Smads."

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"The loss of SMAD4 will abrogate the canonical TGF-b/SMAD4 signaling pathway (24) , and it may make pancreatic cancer more aggressive (25) ."

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"Moreover, SMAD4 overexpression restored the mRNA and protein levels of SMAD4 and cell cycle related genes (P < 0.05)."

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"Data in XREF_FIG show that Smad4 siRNA inhibits the expression of Smad4 in Panc1 cells (XREF_FIG), as well as the stress induced Smad4 like protein in BxPC3 cells (XREF_FIG)."

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"These findings show that SMAD4 binds to mir-205-5p and increases expression of SMAD4 ."

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"Smad4 protein expression was down-regulated in 68.4% (26/38) of the cases but up-regulated Smad 4 expression was seen in only one case."

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"In SMAD4 null HPAC and PANC0327 cells, we reconstituted SMAD4 expression by lentiviral-mediated stable integration of a V5 epitope-tagged SMAD4 cDNA."