IndraLab

Statements

INS increases the amount of INS. 10 / 382
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"For example, in a clinical study of healthy individuals, delivery of intranasal insulin using CPE-215 technology produced peak plasma levels of insulin 10 to 20 min."
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"Of interest, in connection with this, are data showing that venous administration of insulin increases insulin levels acutely in the cerebrospinal fluid XREF_BIBR."
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"We found that in young Lep ob/ob mice, loss of 2 or 3 insulin alleles reduced plasma insulin levels by 75-95% and attenuated body weight gain by 50-90% compared to Ins1 +/+; Ins2 +/-; Lep ob/ob mice."
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"Nonetheless, given that intranasal insulin delivery in 30 min is sufficient to elevate insulin levels in cerebrospinal fluid, these findings are in line with previous reports in rats and dogs, suggesting that direct brain insulin infusion lowers plasma glucose levels independently of changes in food intake."
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"Insulin treatment produced the following significant changes : decreases in blood glucose (at 7.00, 10.00, 16.00), mean daily blood glucose, HbA1, urinary glucose and low density lipoprotein (LDL) cholesterol and increased postglucose immunoreactive insulin (IRI) levels."
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"Downregulation of insulin expression by insulin gene dosage [XREF_BIBR], pharmaceutical suppression of insulin [XREF_BIBR] or fat cell specific insulin receptor knockouts [XREF_BIBR] protect against obesity."
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"Pancreatic output of insulin increased sixfold resulting in threefold increments in transhepatic uptake and arterial serum insulin levels."
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"As the demand for insulin increases, the insulin producing cells in the pancreas gradually lose the ability to produce sufficient amounts of insulin to regulate blood glucose [XREF_BIBR]."
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"Osteocalcin knockout mice exhibited glucose intolerance, increased fat mass, insulin resistance, decreased expression of insulin target genes in liver and muscle, and decreased adiponectin gene expression in adipose [XREF_BIBR], while administration of recombinant osteocalcin increased insulin secretion, decreased blood glycaemia and weaken the development of obesity [XREF_BIBR]."
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"Later studies have also confirmed the above findings, where gestational low protein (6% vs. 20% in control) in rats led to insulin resistance in adult offspring by involving an inadequate insulin induced phosphorylation of the Insulin receptor, insulin receptor substrate-1 (IRS-1) and Akt substrate of 160kDa (AS160) as well as an impaired GLUT4 translocation and the corresponding increases in glucose and insulin levels when subjected to an IGTT (Blesson etal., 2014)."
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Modified INS increases the amount of INS. 10 / 16
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"On the one hand, E2 group has significantly higher insulin levels than others at any days of treatment, and E group has significantly higher insulin levels at day 6 and significantly lower insulin lev[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In IR, insulin levels are abnormally high, increasing the amount of insulin competing with Abeta for IDE in the brain XREF_BIBR, XREF_BIBR, XREF_BIBR."
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"The decrease in Pdx1 and MafA DNA binding activity is associated with the loss of insulin driven reporter activity and insulin mRNA levels, with the change in MafA occurring earlier and correlated more closely with the loss in expression than Pdx1 XREF_BIBR, XREF_BIBR."
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"An increase in fasting insulin levels and glucose stimulated insulin levels during GH treatment has been previously reported in children with short stature born SGA who received long-term GH treatment, suggesting that relative insulin resistance may develop during long-term GH treatment."
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"Infusion of the same amount of insulin into a peripheral vein raised peripheral insulin levels to 14 +/- 1 microU/ml and portal vein concentrations to 12 +/- 1 microU/ml."
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"In contrast, serum insulin levels increased during the first treatment year in all groups, resulting in a more marked elevation of integrated insulin levels in transplant (1402 +/- 179 pM) and dialysis (1025 +/- 114 pM) patients compared with conservatively treated patients (829 +/- 94 pM), and control subjects (719 +/- 89 pM) (p < 0.01)."
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"A reduction in the lipid moiety ceramide, a known inhibitor of insulin transcription, may enhance insulin transcription and content in lipid depleted INS-1 cells [XREF_BIBR]."
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"Under arterial isoglycemia across the groups, the physiological GLP-1 infusion in Sham augmented promptly and markedly arterial insulin levels, approximately twofold the levels in glucose alone infusion (P < 0.005), and insulin levels in Vagox diminished apparently (P < 0.05)."
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"This study clearly demonstrated that expression of insulin as oleosin fusion protein in plant allow accumulation of large amount of recombinant insulin within the seed and also provide simple downstream purification by centrifugation i.e. oilbody purification."
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"These mutants fall into three major phenotypic classes displaying severely reduced insulin expression, reduced insulin expression with abnormal islet morphology, or abnormal islet morphology with relatively normal number of insulin expressing cells."
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INS bound to it increases the amount of INS. 1 / 1
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"Here, we report cloning of the human mafA (hMafA) and demonstrate that it can specifically bind the insulin enhancer element RIPE3b and activate insulin gene expression."
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Unmethylated INS increases the amount of INS. 1 / 1
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"The insulin promoter is specifically demethylated only in pancreatic beta-cells, allowing the expression of insulin [XREF_BIBR]."
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