IndraLab

Statements

EGFR activates SRC. 10 / 214
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"To examine whether c-Src tyrosine kinase is involved in EGFR signaling in response to meningitic E. coli invasion, we performed co-immunoprecipitation and Western blotting to assess the possible recruitment and activation of c-Src by EGFR."
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"EGFR has been reported to activate Src through a variety of mechanisms."
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"For example, we have previously reported that inhibition of epidermal growth factor receptor (an upstream activator of ERK1/2 and Src) blocks endothelial MP mediated responses in cultured mouse aortic endothelial cells [XREF_BIBR]."
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"In breast cancer, EGFR not only activates c-Src but also increases the activity of c-Src."
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"When epithelial cells are stimulated by EGF, c-Src is activated by EGF induced EGF receptor activation [XREF_BIBR]."
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"Indeed, EGFR stimulation triggers the catalytic activity of Src which, in turn, phosphorylates EGFR on unique tyrosine residues."
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"The association between Lyn and PLSCR1 is reminiscent of the association between PLSCR1 and Src in EGF receptor signaling that potentiates Src kinase activity XREF_BIBR, XREF_BIBR."
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"In addition, we and others have demonstrated that targeting Src kinase sensitizes trastuzumab resistant tumors XREF_BIBR, XREF_BIBR independent of EGFR expression."
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"To further explore the functional importance of Y439 phosphorylation, we turned to the H1975 cells, in which Src is activated by mutated EGFR and Rpt2-Y439 phosphorylation was effectively inhibited by saracatinib (XREF_SUPPLEMENTARY)."
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"SRC is activated by EGFR and induces the gene expression of factors necessary for the maintenance of GSCs, such as SOX1, C–X–C chemokine receptor type 4 (CXCR4), distal-less (DLL) protein, and neurogenic locus notch homolog protein 3 (NOTCH3), through the phosphorylation of STAT3 [ xref ]."
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Kinase-active EGFR activates SRC. 5 / 5
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"Expression of wild-type (wt) Cbp remarkably suppressed EGF-induced activation of Src, ERK1/2, and Akt-1 enzymes, and NIH3T3 cell transformation, as well as colony formation of a breast cancer cell line (MDA-MB-468) in soft agar."
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"In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways."
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"from full text - Figure 1 "
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"Figure 1 | The ErbB signalling network."
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"It is known that Cav1 is Src-phosphorylated on tyrosine 14 in response to EGF treatment, although the significance of this modification is unknown."
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EGFR bound to EGF activates SRC. 1 / 1
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"If transactivation of EGFR kinase is an upstream signaling event in the activation of Cl - SAC, exogenous EGF, which binds EGFR kinase and stimulates FAK and Src activity and ROS production, might be expected to mimic the effect of integrin stretch."
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EGFR-Y1086F activates SRC. 1 / 1
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"All four EGFR mutants stimulated downstream signaling in response to EGF, but Y992/1173F EGFR was partially defective in PLCgamma activation whereas both Y1068F and Y1086F EGFR failed to activate Src."
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EGFR bound to HBEGF activates SRC. 1 / 1
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"This suggests that HNSCC cells lacking Abl or treated with imatinib generate an autocrine loop, where increased HB-EGF synthesis and shedding in turn binds and activates EGFR to stimulate Src and Erk activation, leading to elevated cortactin phosphorylation and enhanced invadopodia ECM degradation (XREF_FIG)."
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EGFR-Y1068F activates SRC. 1 / 1
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"All four EGFR mutants stimulated downstream signaling in response to EGF, but Y992/1173F EGFR was partially defective in PLCgamma activation whereas both Y1068F and Y1086F EGFR failed to activate Src."
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EGFR-L858R activates SRC. 1 / 1
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"Compared to wildtype control mice, pErk1/2 and pSrc (Y416) levels were increased in the lungs of Dox induced C/EL858R bitransgenic mice, indicating that EGFR L858R activated Erk1/2 and Src in the lungs of these mice."
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EGFR bound to EB2R activates SRC. 1 / 1
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"Our results show that EGFR homodimers mediate action of EGF at high abundance, but at low abundance, EGF promotes differentiation through EGFR and EB2R heterodimer activation of Src and p38."
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EGFR bound to SRC activates SRC. 1 / 1
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"Furthermore, we found increased EGFR binding to MET and SRC was induced by cetuximab, resulting in MET, SRC, and EGFR complex in Caco-2 cells, whereas no obvious detectable binding was observed in DiFi cells (XREF_FIG)."
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