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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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EGFR activates SRC. 8 / 167
| 1 41 105
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"In xref , experimental results have shown that EGFR activates SRC and is phosphorylated by SRC on Tyr-845, indicating bi-directional relation between EGFR and SRC."
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"Taken together, these in vitro data suggest that the combination of EGFR gene amplification and PTEN deletion in MIBC renders the cells sensitive to treatment with dasatinib and PKI-587 owing to upregulated SRC and AKT signaling pathways."
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"Although activation of c-src by EGF receptor is central to many of its enhanced mitogenic effects, reduction of Cx43 coupling was correlated with serine, not tyrosine phosphorylation."
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"EGFR stimulation increased activation of c-Src in control vector transfected HNSCC cells, but not in dominant negative c-Src expressing cells (XREF_FIG)."
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"To examine whether c-Src tyrosine kinase is involved in EGFR signaling in response to meningitic E. coli invasion, we performed co-immunoprecipitation and Western blotting to assess the possible recruitment and activation of c-Src by EGFR."
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"Inhibition of EGFR has been reported to reduce Src activity to basal levels in colon cancer cell lines."
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"EGFR has been reported to activate Src through a variety of mechanisms."
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"For example, we have previously reported that inhibition of epidermal growth factor receptor (an upstream activator of ERK1/2 and Src) blocks endothelial MP mediated responses in cultured mouse aortic endothelial cells [XREF_BIBR]."
Kinase-active EGFR activates SRC. 5 / 5
5 |
bel
"Expression of wild-type (wt) Cbp remarkably suppressed EGF-induced activation of Src, ERK1/2, and Akt-1 enzymes, and NIH3T3 cell transformation, as well as colony formation of a breast cancer cell line (MDA-MB-468) in soft agar."
bel
"from full text - Figure 1 "
bel
"It is known that Cav1 is Src-phosphorylated on tyrosine 14 in response to EGF treatment, although the significance of this modification is unknown."
bel
"Figure 1 | The ErbB signalling network."
bel
"In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways."
EGFR-L858R activates SRC. 1 / 1
| 1
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"Compared to wildtype control mice, pErk1/2 and pSrc (Y416) levels were increased in the lungs of Dox induced C/EL858R bitransgenic mice, indicating that EGFR L858R activated Erk1/2 and Src in the lungs of these mice."
EGFR bound to EB2R activates SRC. 1 / 1
| 1
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"Our results show that EGFR homodimers mediate action of EGF at high abundance, but at low abundance, EGF promotes differentiation through EGFR and EB2R heterodimer activation of Src and p38."
EGFR bound to SRC activates SRC. 1 / 1
| 1
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"Furthermore, we found increased EGFR binding to MET and SRC was induced by cetuximab, resulting in MET, SRC, and EGFR complex in Caco-2 cells, whereas no obvious detectable binding was observed in DiFi cells (XREF_FIG)."
EGFR-Y1068F activates SRC. 1 / 1
| 1
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"All four EGFR mutants stimulated downstream signaling in response to EGF, but Y992/1173F EGFR was partially defective in PLCgamma activation whereas both Y1068F and Y1086F EGFR failed to activate Src."
EGFR bound to HBEGF activates SRC. 1 / 1
| 1
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"This suggests that HNSCC cells lacking Abl or treated with imatinib generate an autocrine loop, where increased HB-EGF synthesis and shedding in turn binds and activates EGFR to stimulate Src and Erk activation, leading to elevated cortactin phosphorylation and enhanced invadopodia ECM degradation (XREF_FIG)."
EGFR-Y1086F activates SRC. 1 / 1
| 1
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"All four EGFR mutants stimulated downstream signaling in response to EGF, but Y992/1173F EGFR was partially defective in PLCgamma activation whereas both Y1068F and Y1086F EGFR failed to activate Src."
EGFR bound to EGF activates SRC. 1 / 1
| 1
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"If transactivation of EGFR kinase is an upstream signaling event in the activation of Cl - SAC, exogenous EGF, which binds EGFR kinase and stimulates FAK and Src activity and ROS production, might be expected to mimic the effect of integrin stretch."