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EGFR activates SRC. 194 / 214
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"To examine whether c-Src tyrosine kinase is involved in EGFR signaling in response to meningitic E. coli invasion, we performed co-immunoprecipitation and Western blotting to assess the possible recruitment and activation of c-Src by EGFR."
27711202
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"EGFR has been reported to activate Src through a variety of mechanisms."
18594011
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"For example, we have previously reported that inhibition of epidermal growth factor receptor (an upstream activator of ERK1/2 and Src) blocks endothelial MP mediated responses in cultured mouse aortic endothelial cells [XREF_BIBR]."
27313830
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"In breast cancer, EGFR not only activates c-Src but also increases the activity of c-Src."
28625132
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"When epithelial cells are stimulated by EGF, c-Src is activated by EGF induced EGF receptor activation [XREF_BIBR]."
23721065
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"Indeed, EGFR stimulation triggers the catalytic activity of Src which, in turn, phosphorylates EGFR on unique tyrosine residues."
20832399
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"The association between Lyn and PLSCR1 is reminiscent of the association between PLSCR1 and Src in EGF receptor signaling that potentiates Src kinase activity XREF_BIBR, XREF_BIBR."
25289695
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"In addition, we and others have demonstrated that targeting Src kinase sensitizes trastuzumab resistant tumors XREF_BIBR, XREF_BIBR independent of EGFR expression."
25532106
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"To further explore the functional importance of Y439 phosphorylation, we turned to the H1975 cells, in which Src is activated by mutated EGFR and Rpt2-Y439 phosphorylation was effectively inhibited by saracatinib (XREF_SUPPLEMENTARY)."
33603165
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"SRC is activated by EGFR and induces the gene expression of factors necessary for the maintenance of GSCs, such as SOX1, C–X–C chemokine receptor type 4 (CXCR4), distal-less (DLL) protein, and neurogenic locus notch homolog protein 3 (NOTCH3), through the phosphorylation of STAT3 [ xref ]."
29340087
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"In VSMCs, Ang II phosphorylates at both Tyr992 and Tyr1068 sites of EGF receptor which activates c-Src and ERK 1/2."
23277024
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"Since PAFR can activate EGFR [XREF_BIBR, XREF_BIBR] and some GPCRs activate Src pathway in an EGFR dependent manner [XREF_BIBR], we excluded the possibility that PTP1B increased SFK activation indirectly through an EGFR (Epithelial-Growth Factor Receptor) -dependent pathway."
30832675
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"Indeed, induction of EGFRvIII expression in LN229 and EGFRvIII tet-on cells by doxycycline activated Src and ERK1/2 as shown by increased p-Src (Y419) and p-ERK1/2 levels."
33420027
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"Mechanistically, anoikis resistance is controlled by constitutive activation of FAK, EGFR mediated Src activation that leads to MEK and Erk and PI3-K and Akt -1 signaling, increased cytosolic c-Fas-associated death domain like IL-1-converting enzyme like inhibitory protein-long (c-FLIP) that inhibits CD95 induced caspase-8 activation and apoptosis, overexpression of beta-catenin that regulates the function of the LEF and TCF family of transcription factors, and protects cancer cells from suspension induced anoikis."
21749900
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"EGFR stimulation activates Src family kinases (SFK), which mediate a variety of intracellular signaling pathways and are overexpressed or hyperactivated in some cancers."
19208836
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"The EGF and EGFR pathway activates Src in LNCaP cells that are cultured without androgens, probably through the stimulation of the AR and Src complex formation."
25184116
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"EGF treatment induced phosphorylation of EGFR and elicited Src activation, subsequently promoting Akt and NFkappaB (p65) and ERK and c-Jun phosphorylation in MCF-7cells."
27087131
trips
"C-Src is Activated by the EGF Receptor in a Pathway that Mediates JNK and ERK Activation by Gonadotropin-Releasing Hormone in COS7 Cells."
33202981
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"EGFR transactivation can mediate PI3K and Src activation and this receptor can be transactivated by H. pylori (XREF_FIG) [XREF_BIBR]; therefore we next determined the role of EGFR in H. pylori induced AKT activation."
19199544
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"Activation of SRC by EGFR further activates Akt, which leads to both acquired and de novo trastuzumab resistance in breast cancer."
22762204
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"Interference of GDF15 (siRNA or N70Q dominant negative) or EGFR pathway (inhibitor or siRNA for EGFR, SRC or ERK) decreases the resistant-cell survival in culture and tumor growth in mice."
35853851
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"In addition to calcium, EGFR (epidermal growth factor) activates SRC in the model and was inferred to be upregulated in CD and downregulated in UC colon."
34075172
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"Intracellular calcium chelation blocks TZD induced Pyk2 activation; here, Src activation by both TZDs and ciglitazone induced EGFR transactivation were prevented by calcium chelation."
17686966
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"In the model, these kinases are linked to Src activity, which is differently stimulated by EGFR or IR."
19357636
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"We demonstrate that AZD0530 inhibited c-Src activation mediated by EGFR stimulation in HNSCC cells, and significantly suppressed the invasive nature of HNSCC cells in vitro."
18594017
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"Second, EGFR activates c-Src, which in turn results in tyrosine-phosphorylation of nuclear CIC that is not DNA bound, promoting its nuclear export ( xref )."
32029440
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"Present data also suggest that only a portion of the intracellular EGFR, Src and Stat3 protein pools are utilized in the formation of the nuclear complex, raising the possibility that there may be diverse cellular pools of EGFR, Src, or Stat3 with different accessibility limitations."
21573184
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"EGFR activate Src, and it could be also activated by Src [XREF_BIBR]."
27705916
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"EGFR activates Src, a non-receptor protein tyrosine kinase, and Src is known to regulate proteins directly involved in cell proliferation and survival, such as Akt [ xref ]."
35207590
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"In glioma, EGFRvIII did not appear to initiate differential expression of specific SFKs but rather preferentially activated Fyn and c-Src compared with Lyn, Yes, Hck, and Blk."
22490227
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"STAT3 can be tyrosine phosphorylated by the dimerized epidermal growth factor receptor (EGFR), EGFR activated SRC (8, Fig. 3), or by EGFR activated JAK2 [62], but only the latter pathway is regulated by SOCS3."
33037393
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"EGFR mediated Src activation in live HEK293 cells using a FRET based Src reporter showed that polyamine depletion significantly increased Src kinase activity."
22227249
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"The activation of FAK is required for sustained EGFR mediated Src activation and thus confers anoikis resistance [XREF_BIBR]."
24977233
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"Specifically, EGFR induced Src activity leads to phosphorylation of a region within the CAS substrate domain which is essential for Rap1 and alphavbeta5 activation."
19208836
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"Thus, while ligand mediated activation of EGFR causes its internalization in clathrin coated pits followed by degradation (reviewed in [187]), IR mediated EGFR stimulation activates the Src kinase, wh[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27016036
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"During this process, EGFR signaling might activate the Src family kinase fyn, leading to phosphorylation of beta4 on tyrosine, or might activate conventional PKC, leading to beta4 phosphorylation on serine."
15611341
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"Studies of mechanism have variably attributed this to a direct redox dependent increase in EGFR kinase activity, direct redox dependent or indirect EGFR dependent activation of Src kinases, and/or redox dependent inhibition of PTPs."
26157389
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"Nuclear ErbB4 signaling through H3K9me3 is antagonized by EGFR activated c-Src."
23230144
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"Here we uncover a molecular mechanism by which persistent EGFR signaling activates Fyn and Src to enhance glioblastoma invasion and tumor survival in vivo."
19690143
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"Co-inhibition of EGFR and AURKA reduces SRC family kinase activity."
20858866
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"NDRG1 reduces EGFR expression and abrogates EGF induced EGFR activation, subsequently inhibiting the EGFR-c-Src association and c-Src activation."
25860930
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"Furthermore, EGFR mediated Src activation promotes heparin binding EGF like growth factor (HB-EGF) shedding from the surface of cells by ADAM family proteases, which drives autocrine EGFR signaling [XREF_BIBR]."
25995992
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"15 It was shown that gefitinib, an EGFR tyrosine kinase inhibitor, suppressed c-Src activation and invasion in HNSCC."
22077153
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"For example, co-inhibition of EGFR and AURKA would reduce SRC family kinase activity."
25452682
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"EGFR indirectly activates c-Src by binding to Ral-GTPase and then activating the downstream transcriptional activator STAT3. xref Studies had shown that EGFR could promote the phosphorylation and expression of STAT3, which contributes to tumor development. xref , xref For instance, miRNA-7 inhibits the expression of EGFR and thus leads to abnormal activation of STAT3 and expression. xref In this study, we found that EGFR was overexpressed in various kinds of NSCLC cells, compared to healthy lung tissue cells."
32801771
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"EGFR leads to transient activation of Src kinase activity in glioma cells."
21776389
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"To determine whether CaM is implicated in EGFR mediated Src activation in EGFR overexpressing A431 cells, we performed experiments in the presence of the CaM antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and the less potent but not inactive inhibitor N-(4-aminobutyl)-2-naphthalenesulfonamide (W-12)."
26058065
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"The ability of caveolin-1 to inhibit caveolae budding may be overcome by reversible phosphorylation [ xref ], potentially initiated by EGFR-induced Src activation [ xref ]."
19509114
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"Activation of Src kinases by EGF has been demonstrated in vitro only in cells that express very high levels of the EGF receptor [28 ',29], perhaps because the EGF receptor normally activates only a sm[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7612268
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"Activated EGFR is also able to activate c-Src, c-Cbl and PLC-γ1 during mitosis."
25479591
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"Likewise, Src activation and expression levels remained relatively low in the MCF-7 and miR-7KD cell line indicating that expression of EGFR is not sufficient to activate Src kinase (XREF_FIG)."
25532106
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"Src is activated by growth factor receptors, cytokine receptors, and focal adhesion kinase (FAK) ( xref )."
19755386
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"PTPN12 has been reported to interact with and inhibit other kinases, including MAPK, protein tyrosine kinase 2 (PTK2), ERB-B2 receptor tyrosine kinase 2 (ERBB2), EGFR, hepatocyte growth factor receptor (MET), activated CDC42 kinase 1 (ACK1), and the SRC family nonreceptor tyrosine kinase LCK."
27811184
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"In this study we demonstrated that in gefitinib-deprived HCC827 GR5 cells STAT5 was further phosphorylated at the phosphorylation site Tyr 694 residue which is known to be associated with EGFR-dependent Src activation [ xref ], whereas the JAK phosphorylation site Tyr 699 was not modified."
24167634
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"Although activation of c-src by EGF receptor is central to many of its enhanced mitogenic effects, reduction of Cx43 coupling was correlated with serine, not tyrosine phosphorylation."
10085299
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"Although activation of c- src by EGF receptor is central to many of its enhanced mitogenic effects ( xref ; xref ; xref ), reduction of Cx43 coupling was correlated with serine, not tyrosine phosphorylation."
10085299
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"C-Src is activated by the epidermal growth factor receptor in a pathway that mediates JNK and ERK activation by gonadotropin releasing hormone in COS7 cells."
28550137
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"The binding induces EGFR-dependent Src kinase activation, and the active Src subsequently phosphorylates AnxA2."
28528686
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"Notably, hyperactivation of EGFR, which is widely found in most of GBMs including the GSCs in our current study, can activate Src 23, and ERK1/2 can be downstream of EGFR and Src 24."
33420027
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"Gefitinib alone totally inhibited EGFR phosphorylation but also partially inhibited c-Src in all cell lines with a maximum effect after 24h of treatment."
28446239
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"On the other hand, EGFR phosphorylation at tyrosine 845, a SRC kinase phosphorylation site 22 was increased, consistent with PTP1B mediated SRC activation 23."
31873221
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"Interestingly Src, which is activated by EGFR signaling, mediates cell proliferation of both DU-145 and PC-3 cells [XREF_BIBR, XREF_BIBR]."
26734997
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"For example, EGFR-dependent Src kinase activation leads to pY333-β-catenin that promotes its association with the glycolytic enzyme, pyruvate kinase M2."
23246962
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"However, c-Src phosphorylation remained unaffected by AG1478 treatment, posing c-Src upstream EGFR activation."
29348482
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"The lack of complete inhibition induced by GM6001 pretreatment could imply that EGFR transactivation could also be induced independently of ligand shedding by an intracellular calcium mediated mechanism, possibly involving Pyk2 or Src [XREF_BIBR, XREF_BIBR]."
21961726
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"In addition, EGFR also induces Src activation, DNA synthesis and cytoskeleton changes in steroid dependent tumor cells."
21830212
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"These initial studies proposed EGFR-mediated activation of Src as a prerequisite for Ras activity at the Golgi apparatus, as inhibition of Src with PP2 was shown to abrogate translocation of an RBD-GFP probe to the Golgi following EGF stimulation."
36122391
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"Of direct relevance to our present study, it has been demonstrated that gangliosides, including ganglioside GM , promote growth factor-induced proliferation of cells through enhancement of EGFR signaling and activation of Src kinase [61]."
31972222
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"In contrast, EGF stimulated phosphorylation of Tyr 52 RACK1 through epidermal growth factor receptor (EGFR)-mediated activation of the kinase Src."
23652203
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"The knowledge that HPV16 binding activates EGFR signaling in cells and Src is activated as a result of EGFR activation was the basis for further work [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
28528686
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"T. gondii activates EGFR in mammalian cells [XREF_BIBR] and EGFR signaling can activate Src [XREF_BIBR]."
29036202
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"Furthermore, we confirmed that the inhibition pattern of PP2 in GRK2 tyrosine phosphorylation was similar to that induced by EGFR activation and co-expression of constitutively active Src."
29885323
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"EGFRvIII mediated induction of Fn14 expression is Stat5 dependent and requires activation of Src, whereas EGFR regulation of Fn14 is dependent upon Src-MEK and ERK-Stat 3 activation."
29724813
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"C-Src is Activated by the EGF Receptor in a Pathway that Mediates JNK and ERK Activation by Gonadotropin-Releasing Hormone in COS7 Cells."
33202981
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"Since EGFR activation of Src initiates alphavbeta5 mediated migration of FG pancreatic carcinoma cells in vitro and in vivo, we asked whether carcinomas of distinct histological origin would migrate on vitronectin in response to activation of beta5 integrin, EGF, and Src."
19208836
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"Together, these data indicate that the phosphorylation of caveolin-1 occurs via c-Src, which is activated by FAK and the EGF receptor."
24364863
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"EGF receptor-activated Src also phosphorylates dynamin and regulates its self-assembly [43] ."
14597138
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"This interaction depends on transient Tyr-phosphorylation of Tom1L1 through EGFR-activated Src kinases and is likely to be mediated by Grb2 and Shc as bridging proteins."
19798056
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"Src shRNA cells were treated with erlotinib and EGFR shRNA cells were treated with dasatinib to determine the cooperative effects of Src and EGFR inhibition."
21266529
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"In addition to calcium, EGFR (epidermal growth factor) activates SRC in the model and was inferred to be upregulated in CD and downregulated in UC colon."
34075172
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"Furthermore, SRC can be activated by the EGFR and ERBB2 in the ERBB signal pathway for adhesion and migration [XREF_BIBR]."
29560828
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"In fact, EGFR induced activation of Src family kinases (SFK) is necessary and sufficient for induction of migration on vitronectin in vitro and metastasis in vivo."
21963850
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"Thus overexpression of dominant negative c-Src effectively abrogates EGFR mediated c-Src activation in HNSCC cells."
18594017
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"For example, EGF receptor activation stimulates c-Src and PLC-gamma, activating RasGRP3, which activates Rap2B and in turn PLC-epsilon."
18691011
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"As EGFR downstream signaling can also activate the non receptor tyrosine kinase Src, the contribution of Y 573 phosphorylation to MT1-MMP trafficking was evaluated."
19509114
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"EGFR activation of Src initiates αvβ5-mediated migration in FG (express stably mutational active Y527F (SrcA) pancreatic carcinoma cells."
34976811
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"This could be established by direct autophosphorylation or indirect phosphorylation by Src ( xref ), which is in turn activated by EGFR ( xref )."
30145116
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"Furthermore, activation of Src by growth factors and growth factor receptors, such as PDGF(R), EGF(R), and HER2/Neu, has been shown to promote cell proliferation [ xref - xref ]."
12509223
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"EGFR activated Src family kinases maintained a longer persistence of GAB1-SHP2 complexes than EGFR phosphorylation in response to EGF in EGFR mutated H1666 lung adenocarcinoma cells XREF_BIBR."
29483824
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"These results suggest that Shp2CSDA inhibited EGFR L858R -induced Erk1/2 and Src activation in the lungs of these tritransgenic mice."
25730908
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"Biochemically, we showed that the close proximity of IL-17R and EGFR allows the adaptor protein Act1 to recruit c-Src for IL-17A-induced EGFR transactivation and subsequent ERK5 activation, which plays a critical role in IL-17A-dependent expansion of Lrig1 + stem cells, epidermal hyperplasia, and skin tumorigenesis."
30578323
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"As Src family kinases are involved in EGFR transactivation via ADAM metalloproteases, we propose a mechanism by which glucose activates ChREBP and Src to promote HB-EGF gene expression and HB-EGF membrane shedding, respectively, and subsequently EGFR downstream signaling and cell cycle activation (XREF_FIG)."
31882563
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"EGFR activates Src and is phosphorylated by Src on Tyr-845, which has been associated with Stat 5b recruitment and mitogenesis ( xref , xref , xref )."
23942551
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"At least some of this increased CD44 expression results from elevated EGFR levels through a Src-dependent mechanism, consistent with the notion that EGFR promotes constitutive Src activation in MPNSTs."
12730955
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"Estrogen can induce phosphorylation of EGFR, and can directly interact with signal transduction pathways, to activate MAPK, JAK and STAT, SRC, and PI3K signaling pathways downstream of EGFR."
27896218
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"Complicating the interpretation of this issue is the fact that SRC can be activated by EGFR itself, making it difficult to examine whether the action of SRC is upstream or downstream of EGFR activation."
27642633
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"It was shown that HPV16 binding leads to EGFR-dependent Src activation."
28528686
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"Indeed, the inability of EGFR overexpression to induce constitutive basal activation of Src and ERK pathways in P-UAEC could explain the low frequency of endothelial cell cancers."
31550517
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"Importantly in the model, Src is strongly activated by EGFR and more weakly by IR."
19357636
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"These observations indicate that SRC hyperactivity in TZMB resistant BC cells promotes a positive feedback cycle where SRC activates EGFR, HER2, and HER3 which, in turn, can activate SRC."
22482061
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"Both EGFR and nAchR activation are known to stimulate the Src and PI3K and PKC pathways but also interact with and regulate distinct downstream effectors for the modification of cell growth, survival and migration [XREF_BIBR, XREF_BIBR]."
27835612
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"XREF_BIBR, XREF_BIBR EGFR homodimerization and heterodimerization with other EGFR family members leads to enhanced tyrosine kinase activity of the receptor complexes and activation of multiple signaling pathways, such as mitogen activated protein kinase (MAPK), p38 MAPK, phosphatidylinositol 3 '-kinase (PI3K), Src, Crk and Nck."
24096486
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"USP17 is required for Src activation by mutant EGFR."
30409180
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"21,26 On the other hand, the epidermal growth factor receptor phosphorylates and activates Src, which, in turn, phosphorylates Tks5."
19464300
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"STAT3 is activated through directly binding to EGFR, through EGFR-activated SRC (8), or through JAK2 (data not shown)."
33037393
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"DR formation depends on the precise spatial activation of Src at focal adhesions by integrin and EGF receptor signals, in an ILK-dependent manner."
22357970
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"Taken together, these in vitro data suggest that the combination of EGFR gene amplification and PTEN deletion in MIBC renders the cells sensitive to treatment with dasatinib and PKI-587 owing to upregulated SRC and AKT signaling pathways."
27438149
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"EGFR signaling also activates Src kinase to phosphorylate annexin A2."
30981651
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"ErbB-2, another EGFR family receptor kinase, has been shown to activate STAT3 in an Src and JAK2 dependent manner [43]."
17961551
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"EGFR aberrations activate downstream pro-oncogenic signaling pathways, including the MAPK pathway, which is activated by multiple effectors, including G-protein-coupled receptors and the kinase Src."
36516759
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"Signaling of epidermal growth factor receptor (EGFR) in TNBC, which activates Src kinase activation, is one of the major causalities of tumor progression."
34128588
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"The pioneering work of Dr Rous led to the discovery of receptor tyrosine kinases (RTK) including c-Kit, VEGFR, PDGFR, EGFR, FGFR and IGFR, which also activate Src; and specific RTK inhibitors (imatinib, sunitinib, sorafenib) and Src inhibitors (dasatanib, bosutinib) [ xref , xref , xref , xref ]."
32532126
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"The pioneering work of Dr Rous led to the discovery of receptor tyrosine kinases (RTK) including c-Kit, VEGFR, PDGFR, EGFR, FGFR and IGFR, which also activate Src; and specific RTK inhibitors (imatinib, sunitinib, sorafenib) and Src inhibitors (dasatanib, bosutinib) [10,11,12,13]."
32532126
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"In NSCLC cells, the delayed Met phosphorylation was the result of ligand stimulated EGFR activation of c-Src followed by transcription of an unknown protein that enhanced Met phosphorylation."
22235915
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"For instance, if EGFR activation of c-Src and ERK/MAPK causes constriction in VSMCs, how does this then relate to eNOS-dependent NO production in ECs ?"
34746830
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"STAT3 is activated through directly binding to EGFR, through EGFR activated SRC (8), or through JAK2 (data not shown)."
33037393
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"It has been reported that upon activation of beta 2 - or alpha 2 -adrenergic receptors, Src specific Y845-EGFR site could be activated by direct phosphorylation of the EGFR receptor (ligand independent) [XREF_BIBR, XREF_BIBR] or by indirect, ligand dependent mechanisms, as recently reported [XREF_BIBR]."
26571308
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"STAT3 can be tyrosine phosphorylated by the dimerized epidermal growth factor receptor (EGFR), EGFR activated SRC (8, Fig."
33037393
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"Src activation triggered by EGFR contributes to receptor endocytosis and is responsible for simulating ACK1 activity XREF_BIBR, XREF_BIBR."
22952966
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"EGFR-activated Src family kinases maintained a longer persistence of GAB1-SHP2 complexes than EGFR phosphorylation in response to EGF in EGFR-mutated H1666 lung adenocarcinoma cells xref ."
29483824
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"Collectively, these results demonstrate that Dsg2 may be a useful theranostic marker for determining EGFR targeted therapy as well as the Src activation status."
32989241
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"Overall, EGFR activates c-Src, and it further increases the response of EGF/EGFR-activation."
35267574
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"Many growth factor receptors or G-protein-coupled receptors located in the plasma membrane can activate Src, including EGFR, VEGFR, PDGFD or FGFR."
26927178
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"It should be noted that although EGFR activation may also stimulate Src, these data place Src upstream of EGFR signaling in the context of high glucose."
23942551
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"Since EGFR activation of Src initiates αvβ5-mediated migration of FG pancreatic carcinoma cells in vitro and in vivo, we asked whether carcinomas of distinct histological origin would migrate on vitronectin in response to activation of β5 integrin, EGF, and Src."
19208836
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"This phosphorylation is likely caused by EGFR mediated activation of Src kinase, of which Annexin A2 is a known substrate [44]."
32629869
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"XREF_BIBR EGFR activates at least five different signaling pathways : the RAS/RAF/MAPK, the phospholipase C, the PI3K and AKT, the STAT, and the SRC pathways."
21188126
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"Resistant cells obtained from patients treated with ceritinib revealed activation of the EGFR, mitogen activated protein (MAP) kinase, and SRC pathways, and the cells were sensitive to combination therapies with inhibitors for EGFR, MAP kinase-ERK kinase (MEK), and SRC [XREF_BIBR]."
26134262
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"The pathological EGFR expression in glioblastoma is proposed to activate all intracellular mitogenic signalling (PI3K/AKT/mTOR, Raf/MEK/ERK, and Src and STAT pathways) by interacting not only through Grb, JAKs, Src, PI3K, phospholipase C-delta, SH1, SH2, and STAT but also through ErbB2 and ErB3 transactivation [XREF_BIBR, XREF_BIBR]."
27358588
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"EGFR stimulation increased the association of PLCgamma-1 and c-Src in HNSCC cells expressing c-Src or PLCgamma-1, but not in dominant negative c-Src or PLCgamma-1 expressing cells suggesting that c-Src and PLCgamma-1 may interact with each other downstream of EGFR in HNSCC cells (XREF_FIG)."
18594017
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"C-Src is activated by the epidermal growth factor receptor in a pathway that mediates JNK and ERK activation by gonadotropin releasing hormone in COS7 cells."
12750372
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"The EGFR-activated Src family kinase was required for GAB1 phosphorylation and maintenance of the GAB1-SHP2 association, and consequently for the activation of PI3K/AKT signaling xref ."
29483824
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"Moreover, allergen induced IL-33 secretion was also found to involve H 2 O 2 -mediated activation of the tyrosine kinases Src and EGFR [144]."
28578013
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"Hence, despite distinctions in signaling behavior not necessarily related to undifferentiated or differentiated IECs, intestinal epithelial cancer cells commonly display an EGFR mediated sustained activation of Src under anoikis conditions."
19479902
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"In NSCLC cells, the delayed Met phosphorylation was the result of ligand stimulated EGFR activation of c-Src followed by transcription of an unknown protein that enhanced Met phosphorylation."
22235915
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"These results indicate that cetuximab exerts a partial agonistic effect on EGFR, which activates Src kinase and subsequently transactivates IGF-1R and VEGFR-2."
30720056
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"The EGFR activated Src family kinase was required for GAB1 phosphorylation and maintenance of the GAB1-SHP2 association, and consequently for the activation of PI3K and AKT signaling XREF_BIBR."
29483824
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"In fact, EGFR-induced activation of Src family kinases (SFK) is necessary and sufficient for induction of migration on vitronectin in vitro and metastasis in vivo ."
21963850
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"Overexpression of Cbp blocks EGFR mediated Src activation, signaling, and cell transformation, whereas loss of Cbp function has the opposite effect."
21776389
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"EGFR, independent of PRL/PRLR, can activate STAT5 indirectly via c-SRC and drive the expression of target genes involved in cell proliferation and survival."
34572912
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"Then, the EGF receptor activates c-Src and PI3K to lead to JNK activation, whereas ERK activation is mediated by Ras, either directly or via c-Src."
33202981
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"In order to examine the efficacy of combined inhibition of both PLCgamma-1 and c-Src in abrogating HNSCC invasion we first determined strategies to inhibit EGFR mediated c-Src activation in HNSCC cells."
18594017
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"Src is directly activated by EGFR, phosphorylating c-Src on tyrosine 416/418."
23066441
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"Activation of MC1R resulted in phosphorylation of EGFR T669, reportedly being a site for inactivation of the receptor , which led to the speculation that MC1R activation could promote synaptopodin stabilization by inhibiting EGFR induced Src activation."
30356069
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"In xref , experimental results have shown that EGFR activates SRC and is phosphorylated by SRC on Tyr-845, indicating bi-directional relation between EGFR and SRC."
26648121
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"EGFR stimulation increased activation of c-Src in control vector transfected HNSCC cells, but not in dominant negative c-Src expressing cells (XREF_FIG)."
18594017
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"Inhibition of EGFR has been reported to reduce Src activity to basal levels in colon cancer cell lines."
18594011
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"This interaction depends on transient Tyr phosphorylation of Tom1L1 through EGFR activated Src kinases and is likely to be mediated by Grb2 and Shc as bridging proteins."
19798056
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"EGFR phosphorylation activates the PI3K/AKT, MAPK, and SRC signaling pathways involved in cell proliferation, metastasis, and survival [89]."
33665742
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"Moreover, ADAM9 may be activated by protein kinase C and ADAM12 has an SH3 binding site that can recruit Src kinases and Grb-2, both of which are activated by ErbB1 [191]."
16076471
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"Up-regulation of EGFR ligands and EGFR activity stimulates proliferation and activates the SRC pathway to tyrosine phosphorylate PKC-delta, reducing its role as an essential component of the keratinocyte death pathway, thus inhibiting the terminal stage of differentiation."
22908325
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"EGF receptor(s) also activates c-Src upon the ligand binding."
24246580
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"In VSMCs, Ang II phosphorylates at both Tyr992 and Tyr1068 sites of EGF receptor which activates c-Src and ERK 1/2 ( xref , xref )."
23277024
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"Of note, EGFR transactivation increases intestinal epithelial cell motility in a PI3K- and Src dependent manner [XREF_BIBR]."
19199544
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"Activation of EGFR signaling by TMEM16A is further demonstrated by Britschgi et al. showing that TMEM16A knockdown reduced EGFR phosphorylation and subsequently inhibited AKT, SRC, and ERK activation in breast cancer cell lines [XREF_BIBR]."
28893247
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"Furthermore, SRC can be activated by the EGFR and ERBB2 in the ERBB signal pathway for adhesion and migration [ xref ]."
29560828
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"In A431 cells, Src is activated by the EGFR, and inhibition of the EGF receptor results in c-Src inhibition."
10775506
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"It was reasonable that EGFR and FAK could not activate c-Src due to a lack of binding to the SH3 domain of c-Src despite its phosphorylated tyrosines docking to the SH2 domain of c-Src."
34367939
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"EGF receptor (s) also activates c-Src upon the ligand binding."
24246580
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"Thus, EGFR may simultaneously activate c-Src and PI3K to amplify the OT signaling to increase the output of PGF (2 alpha) in bEEL cells."
20080869
reach
"Since both the EGFR and integrin beta3 activated Src [XREF_BIBR, XREF_BIBR], and since Src also caused the reciprocal activation of both receptors, we predicted that polyamines might regulate Src by modulating the interaction between Src, integrinbeta3 and the EGFR."
22227249
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"However, SRC activation by PGE 2 does not involve the tyrosine kinase activity of EGFR suggesting that SRC is activated by PGE 2 upstream of EGFR, subsequently leading to EGFR activation and nuclear localization."
28415726
eidos
"Epidermal Growth Factor Receptor ( EGFR ) Epidermal growth factor ( EGF ) and hepatocyte growth factor ( HGF ) activate Src through the formation of Src / EGFR and c-Met receptor complexes , respectively , which markedly enhance the invasiveness of CRC cells ( Figure 1 ) ."
32456226
reach
"Considering a substantial Src contribution to GAB1 phosphorylation under various conditions, the model explains this observation by the fact that Src is preferably activated by EGFR and not by IR."
19357636
reach
"Intestinal epithelial cancer cells commonly display EGFR mediated sustained activation of Src interacting with FAK and consequent MEK and Erk activation to resist anoikis [XREF_BIBR]."
22988500
reach
"P2Y (2) R activation induces the phosphorylation of the epidermal growth factor receptor (EGFR), a response dependent upon the presence of a SH3 binding domain in the intracellular C terminus of the P2Y (2) R that promotes Src binding and transactivation of EGFR, a pathway that regulates the proliferation of cortical astrocytes."
20387013
reach
"Activated c-Src then phosphorylates the EGFR, which leads to increased association of Shc and Grb2 and Sos with the EGFR, and subsequent activation of Ras, Raf-1 and MEK-1/2 [29]."
11306244
reach
"For example, amplification of the EGF receptor in breast cancer cells, or activation of Abl by the BCR-ABL translocation in chronic myelogenous leukemia, activates Src or Abl kinases and targets p27 for degradation XREF_BIBR, XREF_BIBR."
19146381
reach
"Src can be activated by EGFR via a Ral-GTPase-dependent mechanism."
17635937
sparser
"Src can be activated by EGFR via a Ral-GTPase–dependent mechanism ( xref )."
17635937
sparser
"This is achieved by EGF receptor-dependent activation of Src tyrosine kinase, leading to phosphorylation and redistribution of clathrin, a major player in ligand-induced endocytosis ( xref )."
14581459
reach
"Using HaCaT keratinocytes, knockdown of Dsg2 decreases EGFR expression and abrogates the activation of EGFR, c-Src and Stat3, but not Erk1/2 or Akt, in response to EGF ligand stimulation."
26918609
reach
"In previous studies, we determined that EGFR mediated Src activation leads to the tyrosine phosphorylation of CAS, a focal contact localized scaffolding protein previously linked to cell migration and invasion."
21963850
reach
"At least some of this increased CD44 expression results from elevated EGFR levels through a Src dependent mechanism, consistent with the notion that EGFR promotes constitutive Src activation in MPNSTs."
12730955
reach
"Kinases, which were phosphorylated to a lower degree in the presence of CSMD1 in statistically significant manner included : epidermal growth factor receptor (EGFR), Akt1/2/3, glycogen synthase kinase-3 (GSK-3), extracellular signal regulated kinases (ERK1/2), mitogen- and stress activated kinases-1 and -2 (MSK 1/2), oncogene p53, focal adhesion kinase (FAK), SRC kinases Lyn and Yes, as well as STAT2."
27764775
reach
"We found that in H1666 lung adenocarcinoma cells, EGFR activated Src family kinases (SFKs) counteracted repeated GAB1 dephosphorylation events and maintained the association of SHP2 with phosphorylated GAB1 at a cytosolic site distal from EGFR."
25969544
sparser
"To further explore the functional importance of Y439 phosphorylation, we turned to the H1975 cells, in which Src is activated by mutated EGFR and Rpt2-Y439 phosphorylation was effectively inhibited by saracatinib ( xref )."
33603165
reach
"EGFR activated Src family kinases maintain GAB1-SHP2 complexes distal from EGFR."
25969544
reach
"We further found that both S1P and EGFR activations occurred in response to the same E. coli proteins (OmpA, FimH, NlpI), and that S1P and EGFR promoted E. coli invasion of the BBB by activating the downstream c-Src."
27711202
sparser
"When Tks4 is phosphorylated by the EGFR-activated Src kinase, it interacts with cortactin to regulate the actin cytoskeleton."
30962481
sparser
"We found that in H1666 lung adenocarcinoma cells, EGFR-activated Src family kinases (SFKs) counteracted repeated GAB1 dephosphorylation events and maintained the association of SHP2 with phosphorylated GAB1 at a cytosolic site distal from EGFR."
25969544
reach
"In this study, we showed that miR-1178 over-expression increased the EGFR protein level and activated the downstream AKT and p21 pathway and the Src and E-cadherin pathway."
25635996
sparser
"For example, EGFRvIII phosphorylates SFKs, which further activate dedicator of cytokinesis 1 (DOCK1). xref DOCK1 plays critical roles in mediating cell growth and migration, contributing to the pro-tumorigenic function of EGFRvIII. xref , xref EGFRvIII can also increase phosphorylation of DOCK1 through PKA. xref EGFRvIII forms a complex with the cytokine receptor OSMR, which regulates the EGFRvIII-STAT3 signaling axis. xref Additionally, SFK activation promotes mitochondrial localization of EGFRvIII, and increases cell survival under low glucose conditions. xref Moreover, EGFRvIII activates hepatocyte growth factor receptor (MET), which in-turn drives STAT3. xref , xref EGFRvIII also activates c-SRC, which promotes secretion of vascular endothelial growth factor (VEGF) and angiogenesis. xref Phosphorylation of these kinases further activates downstream signaling pathways and contributes to tumor progression."
29321659
sparser
"EGFR activate Src, and it could be also activated by Src [ xref ]."
27705916
reach
"This in turn up-regulates epidermal growth factor receptor (EGFR) signaling to mediate Src activation, leading to E-cadherin ubiquitination and lysosomal degradation."
18057010
reach
"These effects of OVA and PTP-I were abolished by inhibitors of Src (PP2 and Src inhibitor No. 5) and EGFR (AG1478 and EGFR inhibitor-1), but not by Rho-kinase inhibitors, confirming that EGFR is a downstream effector of Src, and an upstream effector of Rho-kinase."
25505586
sparser
"Thus, EGFR may simultaneously activate c-Src and PI3K to amplify the OT signaling to increase the output of PGF(2 alpha) in bEEL cells."
20080869
reach
"Yet, when EGFR and c-Src cross talk is eliminated by loss of EGFR tyrosine 845 phosphorylation, either by mutation or Src kinase inhibi-tion, p38 MAPK phosphorylation is abrogated."
23066441
reach
"Activation of SRC by EGFR further activates Akt, which leads to both acquired and de novo trastuzumab resistance in breast cancer."
22762204
reach
"Activated Src and Ras induce gefitinib resistance by activation of signaling pathways downstream of epidermal growth factor receptor in human gallbladder adenocarcinoma cells."
16532343
reach
"Taken together, these date indicate that c-Src activation mediated by EGFR likely contributes to the invasiveness and metastatic potential of HNSCC cells."
18594017
sparser
"In A431 cells, Src is activated by the EGFR, and inhibition of the EGF receptor results in c-Src inhibition."
10775506
reach
"In that study, Src activation by hydrogen peroxide induced EGFR transactivation without phosphorylation of Tyr1173, an autophosphorylation site of the activated EGFR [20]."
16414009
sparser
"In pancreatic cancer, epidermal growth factor receptor (EGFR) induced Src activation, followed by the phosphorylation of p130Cas/BCAR1 [ xref ]."
32906721