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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

EGFR bound to HBEGF activates SRC. 1 / 1

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"This suggests that HNSCC cells lacking Abl or treated with imatinib generate an autocrine loop, where increased HB-EGF synthesis and shedding in turn binds and activates EGFR to stimulate Src and Erk activation, leading to elevated cortactin phosphorylation and enhanced invadopodia ECM degradation (XREF_FIG)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...