IndraLab

Statements

EGF leads to the phosphorylation of EIF4EBP1. 10 / 25
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"Hormones (insulin, angiotensin), growth factors (EGF, PDGF, NGF, IGFI, IGFII), cytokines (IL-3, GMCSF+ steel factor), mitogens (TPA), G protein coupled receptor ligands (gastrin), and adenovirus infec[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Both EGF and NGF induced phosphorylation of PHAS-I (Fig. 1), which released eIF4E from PHAS-I (Fig. 2A), mak- ing eIF4E available for translation [5,13]."
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"We highlighted that 4E-BP1 phosphorylation was not activated by epidermal growth factor (EGF) but was under an insulin regulation mechanism through a PI3K-FRAP and mTOR activation that could account for the permissive role of insulin on hepatocyte proliferation."
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"EGF induced a rapid phosphorylation of Akt, tuberin, p70S6K and 4E-BP1 (XREF_FIG)."
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"Effect of rapamycin on NGF- and EGF-induced PHAS-I and MAPK phosphorylation."
8914981
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"Effect of staurosporine on NGF- and EGF-induced PHAS-I and MAPK phosphorylation."
8914981
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"In H28V cells, both S6K and 4EBP1 are markedly phosphorylated in response to EGF treatment, higher than in H28T7 cells, with S6K exhibiting a more transient response as compared with 5AT1; while that of 4EBP1 showed a similar pattern in these two sets of cells (XREF_FIG)."
21701776
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"We highlighted that 4E-BP1 phosphorylation was not activated by epidermal growth factor (EGF) but was under an insulin-regulation mechanism through a PI3K-FRAP/mTOR activation that could account for the permissive role of insulin on hepatocyte proliferation."
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"Treatment of HT29 cells with AR inhibitor, fidarestat, prevented the EGF-induced phosphorylation of mTOR, Raptor, eIF4E, S6K and 4E-BP1 and increased the phosphorylation of AMPK."
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"We determined that EGF activates phosphorylation of Akt, mTOR, p70S6 kinase, ribosomal protein S6, eIF4E and 4E-BP1 in a PI-3-kinase dependent manner, and PI-3-kinase activation may prevent lactogenic differentiation in HC11 mammary epithelial cells by regulating the synthesis of proteins."
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EGF leads to the phosphorylation of EIF4EBP1 on S85. 2 / 2
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bel
"We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database"
17081983
bel
"We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database"
17081983
EGF leads to the phosphorylation of EIF4EBP1 on S65. 1 / 1
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bel
"We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database"
17081983
EGF leads to the phosphorylation of EIF4EBP1 on S101. 1 / 1
1 |
bel
"We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database"
17081983
EGF leads to the phosphorylation of EIF4EBP1 on S83. 1 / 1
1 |
bel
"We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database"
17081983
Modified EGF leads to the phosphorylation of EIF4EBP1. 1 / 1
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"Biochemical analyses confirmed that CC214-1 successfully inhibited mTORC1 dependent 4E-BP1 and S6 phosphorylation in EGFRvIII expressing GBM cells (XREF_FIG and XREF_SUPPLEMENTARY, XREF_SUPPLEMENTARY), as well as blocked EGF induced 4E-BP1 and S6 phosphorylation in GBM cells overexpressing wild type EGFR (XREF_SUPPLEMENTARY)."
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