PI-3 kinase blocked NGF- and EGF-induced PHAS-I phosphorylation in
"Collectively, these results suggest that AR inhibition prevents EGF-induced PDCD4 and 4E-BP1 phosphorylation via regulation of mTOR/Raptor/S6K pathway."
"As shown in xref , EGF-induced phosphorylation of mTOR, 4E-BP1, and P70S6K was significantly decreased in SiNUAK1/H1299 cells compared with Scr/H1299 cells."
"Effect of rapamycin on NGF- and EGF-induced
PHAS-I and MAPK phosphorylation."
"EGF induced a rapid phosphorylation of Akt, tuberin, p70S6K and 4E-BP1 ( xref )."
staurosporine on NGF- and EGF-induced PHAS-I and MAPK phosphorylation."
"NGF- and EGF-induced PHAS-I phosphorylation was also studied in the
presence of the PI-3 kinase inhibitor wortman- nin, the PKC inhibitor
staurosporine, and the FRAP inhibitor rapamycin, to determi[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
"Both EGF and NGF induced
phosphorylation of PHAS-I (Fig. 1), which released eIF4E from PHAS-I
(Fig. 2A), mak- ing eIF4E available for translation [5,13]."
"Since mTOR causes the phosphorylation of downstream targets such as eIF4E, S6K and 4E-BP1, we next examined the affect of AR inhibition on EGF-induced phosphorylation of eIF4E, S6K and 4E-BP1 in HT-29 cells."
"Both EGF and NGF induced phosphorylation of PHAS-I."